天然产物Rubraflavone A的三甲氧基化合物的合成  

Synthesis of Intermediate of Rubraflavone A

作　　者：齐帅[1] 陈乾[1] 王小强[1] 黄初升[1] 刘红星[1] 

机构地区：[1]广西师范学院化学系,广西南宁530001

出　　处：《化工技术与开发》2008年第4期1-3,共3页Technology & Development of Chemical Industry

基　　金：国家自然科学基金(批准号20062001)资助

摘　　要：以2,4-二羟基苯乙酮和2,4-二甲氧基苯甲酸为起始原料依次经过成酯、Claisen重排、香叶基取代、酸性条件下关环4步反应,以13.5%的总收率合成了天然产物Rubraflavone A的三甲氧基化合物。其关键步骤包括香叶基的引入和引入后的关环反应。The trimethoxy compound of rubraflavone A was designed and synthesized under mild conditions. The structures of all the compounds were characterized by 1H NMR and ^13C NMR. The synthetic route was completed from 2,4-dihydmxy acetophenone and 2,4-dimethoxybenzoie acid through four steps. The first step was elaisen rearrangement of compound （3） in the presence of potassium hydroxide and pyridine to give 1,3-diaryl-β-propanedione （4）. Then compound （4） was alkylated with geranyl brmide. Finally, compound （5） was eyelized via concentrated sulfuric acid in methanolto give the compound （6）.

关 键 词：香叶基溴 3-香叶基黄酮 Rubraflavone A 合成 

分 类 号：O621.3[理学—有机化学]