低通气综合征患者血浆食欲素A水平及代谢紊乱的影响  

Effects of nasal continuous positive airway pressure on plasma orexin-A concentration and the metabolic parameters in obstructive sleep apnea hypopnea syndrome

作　　者：欧阳松云[1] 王辰[2] 庞宝森[2] 詹玉梅[2] 

机构地区：[1]郑州大学第一附属医院老年病科,450052 [2]首都医科大学附属北京朝阳医院京西院区-北京呼吸疾病研究所

出　　处：《中国实用医药》2008年第12期59-60,共2页China Practical Medicine

摘　　要：目的评价经鼻持续气道内正压通气(nCPAP)对阻塞性睡眠呼吸暂停低通气综合征(OS-AHS)患者食欲素A(orexin-A)及代谢紊乱的影响。方法测定23例OSAHS患者在nCPAP治疗前及治疗12个月血浆食欲素A水平及部分代谢参数的变化。结果治疗12个月患者血浆食欲素A水平、ESS评分、微觉醒指数(MAI)、血胆固醇(Chol)、甘油三酯(TG)均较治疗前明显降低,高密度脂蛋白(HDL)升高,差异有统计学意义(P均为<0.05);治疗前后体质量指数(BMI)无明显改变(P>0.05);OSAHS患者血浆食欲素A水平与AHI及MAI呈正相关(r=0.542,0.671,P<0.05),与夜间最低血氧饱和度(LSO2)呈负相关(r=-0.611,P<0.05),与BMI无相关性(r=0.311,P>0.05)。结论OSAHS患者血浆食欲素A水平升高,并与病情严重程度相关;长期nCPAP治疗能改善血浆食欲素A水平及脂质代谢紊乱。Objective To evaluate the effects of nasal continuous positive airway pressure （nCPAP） on plasma orexin-A level and the metabolic parameters in patients with obstructive sleep apnea hypopnea syndrome. Methods 23 Patients whose plasma orexin-A levels and the metabolic parameters were reexamined before therapy and after 12 months nCPAP therapy. Results The plasma orexin-A levels in the OSAHS group were significantly higher than those in the control group. After 12 months of nCPAP therapy, the plasma orexin-A levels were decreased, and the metabolic parameters were improved. Conclusion OSAHS may cause the increase of the plasma orexin-A level and metabolic disturbance. The correction of sleep disordered breathing by 12 months nCPAP treatment can reduce the plasma orexin-A level, and can improve metabolic disturbance.

关 键 词：经鼻持续气道内正压 阻塞性睡眠呼吸暂停低通气综合征 食欲素A 

分 类 号：R56[医药卫生—呼吸系统]