静脉注射丙种球蛋白治疗川崎病疗法评估  

Evaluation of the different modalities with intravenous immunoglobulin infusion in treatment of Kawasaki disease

作　　者：杨霏霏[1] 倪岩 

机构地区：[1]大连市友谊医院,116000 [2]大连市建国医院

出　　处：《中国现代药物应用》2008年第9期23-25,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨应用静脉丙种球蛋白(IVIG)治疗小儿川崎病(KD)不同疗法的效果。方法收集2005-2007年间我院应用IVIG治疗川崎病患者57例,对5d疗法(0.4g/kg,连用5d)、2d疗法(1g/kg,连用2d)、1天疗法(2g/kg,用1d)进行疗效对比。结果在发热消退、结膜充血恢复、血沉恢复、口腔改变的恢复方面,1天疗法与2天疗法疗效显著,与5天疗法比较,差异有统计学意义(P<0.01);在颈淋巴结消退、C-反应蛋白、心电图的恢复方面,三种疗法比较,差异无统计学意义(P>0.05);在预防冠状动脉扩张(CAD)方面,1天疗法、2天疗法疗效显著,与5天疗法比较,差异有统计学意义(P<0.01)。结论1天疗法与2天疗法在疗效方面明显优于5天疗法,1天疗法输入蛋白量为2000mg/kg,会使患儿血浆胶体渗透压短时间内骤升,而2天疗法1天输入蛋白量为1000mg/kg,对小儿的血浆胶体渗透压影响较小,因此2天疗法更优于1天疗法。Objective To evaluate effects of three modalities with intravenous immunoglobulin（IVIG） infusion in the treatment of Kawasaki disease（KD） . Methods 57 cases with KD were treated by the IVIG in the Department of Pediatric of Friend Hospital of Dalian City from 2005 to 2007. The three modalities were as follows ： five-day treatment （0. 4 g/kg ,for five days continuance） ,two-day treatment （1 g/kg ,for two days continuance） , one-day treatment （2 g/kg ,for one day） . Results （ 1 ） In treatment of fever , conjunctiva congest and mouth change , and recover in erythrocyte sedimentation , one-day treatment and two-day treatment had better curative effect with significantly difference（P 〈 0. 01 ） , compared with five-day treatment. （2） In the extinction of lymphonodi cervicales, C-RP and electrocardiogram , there was no difference among the three modalities（P 〉 0. 05） . （3） In the prevention of coronary artery dilate （CAD） , one day treatment and two days treatment had better curative effects significantly difference（ P 〈 0. 01 ） compared with five-day treatment. Conclusions One-day treatment and two-day treatment have better curative effect, and the two-day treatment is a much better modality with no change of osmotic pressure and less infusion of albumin in the treatment of children＇ s KD.

关 键 词：川崎病 静脉丙种球蛋白 治疗方法 临床分析 

分 类 号：R725.4[医药卫生—儿科]