辛伐他汀对骨质疏松大鼠骨代谢的影响  

Effects of simvastatin on bone metabolism in osteoporosis rats

作　　者：杜志斌[1] 陈江[1] 黄文秀[1] 简小冲[1] 闫福华[1] 

机构地区：[1]福建医科大学附属口腔医院种植中心,福州350002

出　　处：《中华口腔医学研究杂志（电子版）》2008年第1期33-37,共5页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：福建省科技攻关计划重点项目(2003Y025);福建医科大学教授学术发展基金(JS06104)

摘　　要：目的观察辛伐他汀对骨质疏松大鼠骨代谢的影响。方法将54只雌性SD大鼠随机分为假手术组、卵巢切除组和卵巢切除加辛伐他汀组,每组18只。适应性喂养后进行造模手术。8周时确认大鼠形成骨质疏松后开始给药,实验组给予辛伐他汀5mg·kg-1·d-1;其余两组用等量生理盐水灌服。分别在第12、20周时分两批处死大鼠,取血观察各组大鼠的碱性磷酸酶、钙、磷、骨源性碱性磷酸酶(BALP)、骨钙素(BGP)的代谢情况。结果与对照组相比,12周时卵巢切除加辛伐他汀组的血清BALP水平升高(3.73±0.46,P<0.01),20周时血清BGP水平升高(9.24±1.98,P<0.01);与12周比较,20周时假手术组、卵巢切除组和卵巢切除加辛伐他汀组的大鼠血清BALP水平均下降(2.33±0.77,1.50±0.34,2.22±0.28,P<0.05,P<0.01),卵巢切除组的血清BGP水平也显著下降(4.02±0.72,P<0.05)。结论辛伐他汀能够显著影响大鼠的骨代谢,辛伐他汀对去卵巢大鼠有促进成骨的作用。Objective To investigate the effect of Simvastatin on bone metabolism in Osteoporosis rats. Methods Fifty four female SD Rats aged 3 months were divided into three groups by randomized block design. They were Sham-operated groups （SHAM）, ovariectomized group （OVX） and Simvastatin with ovariectomized rats group （OVX＋SIM）. When osteoporosis model was established at 8 weeks, Simvastatin were administered orally 5 mg·kg^-1·d-^-1to OVX＋SIM group and normal saline to the other two groups. The rats were sacrificed separately at 12th week and 20th week. Blood sample were collected to obtain serum levels of alkaline phosphatase （ALP）, Ca, P, bone specific alkaline phosphatase （BALP）, and bone gla protein （BGP） at the time of killing. Results The level of BALP was significantly increased in the OVX＋SIM group as compared with two other groups at 12 weeks （3.73±0.46, P 〈 0.01）. At 20 weeks, the level of BGP in the OVX＋SIM group was significantly increased too （9.24±1.98, P 〈 0.01）. Compared with 12 weeks, the levels of BALP were significantly decreased at 20 weeks in all groups（2.33±0.77, 1.50±0.34, 2.22±0.28, P 〈 0.05, P 〈 0.01 ）, and the level of BGP of OVX group was significantly decreased too （4.02±0.72, P 〈 0.05）. Conclusion Our results demonstrate that Simvastatin can affect bone metabolism and has a general beneficial effect on bone formation of Osteoporosis rats.

关 键 词：辛伐他汀 骨钙素 碱性磷酸酶 骨代谢 骨质疏松 

分 类 号：R580[医药卫生—内分泌]