葡萄膜炎自身抗原表位的研究  

Studies on autoantigenic epitopes involving in the development of uveitis

作　　者：赵长霖[1] 杨培增[1] 

机构地区：[1]中山大学中山眼科中心眼科学国家重点实验室中山大学葡萄膜炎研究中心广东省国际葡萄膜炎研究实验室,广州510060

出　　处：《中华眼科杂志》2008年第4期377-380,共4页Chinese Journal of Ophthalmology

摘　　要：多种抗原参与自身免疫性葡萄膜炎的发生发展，但是这些抗原的免疫优势表位尚不明确。针对视网膜S抗原等葡萄膜炎自身抗原免疫表位的研究显示，每种抗原蛋白均存在多个可诱导易感动物葡萄膜炎发作的致病位点，每种抗原均存在多个可诱导葡萄膜炎患者产生体外细胞免疫反应的免疫原性表位，同种抗原的致病表位和免疫原性表位不完全一致。葡萄膜炎患者对于各抗原表位肽的反应性显示出高度异质性，表现为不同患者对不同肽发生反应和同一例患者在不同时期对不同肽发生反应。由此，提出了葡萄膜炎表位扩展现象，并利用动物实验得以证实。表位扩展可能是自身免疫反应的防御现象，但是自身免疫反应的多样化同时又对抗原特异性耐受疗法提出了挑战。It has been proposed that a few kinds of autoantigens imitate the development of autoimmune uveitis while the immunedominant epitopes of these antigens have not been identified. Researches on retinal S-antigen and interphotoreceptor retinoid-binding protein as well as tyrosinase-related protein epitopes mapping have shown that each autoantigen contains several immunopathogenic epitopes and immunogenic epitopes and that the immunopathogenic sites are not coincident with the immunogenic epitopes. The reactivity of peripheral blood mononuclear cells from uveitis patients against each autoantigenic epitopes displays high heterogeneity. Epitopes spreading phenomenon has been disclosed in human uveitis study and reinforced in animal experiments. Study on this epitope spreading may contribute to our understanding of immune tolerance induced by different epitopes in the treatment of autoimmune disease including uveitis.

关 键 词：葡萄膜炎 自身免疫疾病 自身抗原 表位 T淋巴细胞 免疫显性表位 

分 类 号：R686[医药卫生—骨科学]