Recent Advances in Research on Hepadnaviral Infection in the Woodchuck Model  

作　　者：Ina Schulte E-juan ZHANG Zhong-ji MENG Rong-juan PEI Mengji LU Michael Roggendorf 

机构地区：[1]Institute of Virology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany [2]Department of Microbiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan,430030, China [3]State Key Lab of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan,430071, China

出　　处：《Virologica Sinica》2008年第2期107-115,共9页中国病毒学（英文版）

基　　金：Deutsche Forschungsgemeinschaft (Lu 669/2-1, GRK1045/1, and Lu 669/5-1)

摘　　要：The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B

关 键 词：Chronic hepatitis B Woodchuck hepatitis virus （WHV） Hepatitis B virus （HBV） 

分 类 号：R512.6[医药卫生—内科学]