木犀草素脂质体制剂处方和工艺优化研究  

Optimization of preparation and formulation of luteolin liposomes

作　　者：幸海燕[1] 王昆[1] 赵凯[1] 张敬如[1] 黄复生[1] 

机构地区：[1]第三军医大学基础医学部病原生物学教研室,重庆400038

出　　处：《第三军医大学学报》2008年第9期810-813,共4页Journal of Third Military Medical University

摘　　要：目的优化制备注射用木犀草素脂质体的处方工艺。方法采用薄膜分散法和冻干工艺进行木犀草素脂质体制备,并以载药量、包封率为评价指标,优化制备处方和工艺。结果木犀草素脂质体制备的最佳工艺处方为磷脂∶木犀草素10∶1,磷脂∶胆固醇4∶1,水化介质为注射用水,温度为50℃。按照此处方工艺制备的木犀草素脂质体平均载药量、平均包封率、平均粒径分别为7.21%、66.8%、278.4nm。结论按优化处方和工艺制备的木犀草素脂质体各项指标基本符合静脉应用要求。Objective To optimize the preparation and formulation of intravenous luteolin liposomes. Methods Luteolin liposomes were prepared by thin-film dispersion method and lyophillization. Optimization of preparation and formulation was accomplished by evaluating the drug-loading amounts and the entrapment efficiency of luteolin liposomes. Results The ideal combination of preparation and formulation was phospholipids： luteolin-10： 1; phospholipids： cholesterin -4： 1. Hydrating medium was distilled water, and temperature was 50 ℃. The average drug-loading, entrapment deficiency, and the average particle size of the optimized liposome was 7.21% , 66.8% and 278.4 nm respectively. Conclusion The optimized luteolin liposomes are proved to be qualified for intravenous injection.

关 键 词：木犀草素 脂质体 包封率 载药量 

分 类 号：R282.71[医药卫生—中药学] R283.6[医药卫生—中医学]