中药知母中的一个新皂苷  

A new furostanol saponin from Anemarrhena asphodeloides Bge.

作　　者：张玉晶[1] 宋少江[1] 马志强 张立平[1] 梁啸[1] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016 [2]哈尔滨制药集团中药二厂,黑龙江哈尔滨150078

出　　处：《沈阳药科大学学报》2008年第4期279-281,共3页Journal of Shenyang Pharmaceutical University

摘　　要：目的对中药知母进行化学成分的分析研究。方法通过硅胶柱色谱和高效液相色谱等手段分离,利用理化性质和光谱方法鉴定。结果得到1个化合物,鉴定为(5β,25R)-26-O-β-D-吡喃葡萄糖基-呋甾-22-甲氧基-3β,26-二羟基-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖苷。结论该化合物为未见文献报道的新化合物,命名为知母皂苷BⅤ(timosaponin BⅤ)。Objective To study the constituents of the extract from the rhizome of Anemarrhena asphodeloides Bge.Methods A chemical constituent was isolated by silica gel and HPLC.Physico-chemical properties and spectroscopic analysis were employed for the structural identification.Results Compound 1 was obtained and its structure was identified as（5β,25R）-26-O-β-D-glucopyranosyl-furostanol-22-methoxyl-3β,26-diol-3-O-β-D-glucopyranosyl（1→2）-β-D-galacopyranoside.Conclusions Compound 1 is a new saponin which has not been reported before,named timosaponin BⅤ（1）.

关 键 词：知母 知母皂苷BⅤ 波谱分析 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]