还原型谷胱甘肽治疗急性缺血性脑卒中52例  

Clinical Effect of Reduced Glutathione on Acute Cerebral Arterial Thrombosis in 52 Cases

作　　者：黄胜立[1] 余桂翔[1] 刘开渊[1] 方忠健[1] 

机构地区：[1]南京军区福州总医院九五临床部,福建莆田351100

出　　处：《中国药业》2008年第9期61-62,共2页China Pharmaceuticals

摘　　要：目的评价还原型谷胱甘肽治疗急性缺血性脑卒中的临床疗效与安全性。方法将52例患者随机均分为治疗组与对照组,治疗组在发病48h内加用还原型谷胱甘肽治疗,治疗前后采用斯堪的纳维亚卒中量表(SSS)评分,并观察不良反应。结果治疗2周后两组神经功能均有显著改善(P<0.01),治疗组改善更显著(P<0.01)且未出现严重不良反应。结论急性缺血性脑卒中发病后48h内应用还原型谷胱甘肽治疗,可有效改善患者神经功能,且无严重不良反应。Objective To evaluate the clinical efficacy and safety of reduced glutathione on the patients with acute cerebral arterial thrombosis. Methods Fifty- two patients were randomly divided into two groups. The treatment group receiving an additional reduced glutathione within 48 h after the onset of ACAT, The nervous functions were evaluated by Scandinavian Stroke Scale （SSS） before and after treatment, and the adverse effects were surveyed after treatment. Results The nervous functions were improved in both two groups （P〈0.01）, and reduced glutathione afforded a higher SSS score without severe adverse effects, compared with the control group （P〈0.01）. Conclusion Use of reduced glutathione within 48 h after the onset of ACAT may efficiently improve the nervous functions without severe adverse effects.

关 键 词：还原型谷胱甘肽 急性缺血性脑卒中 疗效 

分 类 号：R969.4[医药卫生—药理学] R972[医药卫生—药学]