The Aggregation Behavior and Formation of Nanoparticles of Oleoylchitosan in Dilute Aqueous Solution  

作　　者：LI Yanyan CHEN Xiguang SUN Gangzheng XING Ke 

机构地区：[1]College of Marine Life Sciences, Ocean University of China, Qingdao 266003, P. R. China

出　　处：《Journal of Ocean University of China》2008年第2期199-204,共6页中国海洋大学学报（英文版）

基　　金：financial support from the National Natural Science Foundation of China(No.30370344);the Scientist Encouragement Foundation of Shandong Province(2004BS7001).

摘　　要：Oleoylchitosans (O-chitosans) with different degrees of substitution (DS) were synthesized by reacting chitosan with oleoyl chloride. The chemical structures of the products were characterized by 1H NMR and FT-IR. These results suggested the for- mation of an amide linkage between the amino groups of chitosan and the carboxyl groups of oleic acid. The viscosity of O-chitosan sharply increased with the increase of concentration, whereas that of unmodified chitosan rose only slightly. This increase became larger as the DS increased. All of the O-chitosans could reduce surface tension slightly. The critical aggregation concentration (CAC) of O-chitosans with DS 5%, 11%, and 27% were 79.43 mgL-1, 31.6 mgL-1, and 10 mgL-1, respectively. Nanoparticles were prepared using an O/W emulsification method. The mean diameters of the polymeric amphiphilic nanoparticles of O-chitosans with DS 5% and 11% were around 327.4 nm and 275.3 nm, respectively.Oleoylchitosans （O-chitosans） with different degrees of substitution （DS） were synthesized by reacting chitosan with oleoyl chloride. The chemical structures of the products were characterized by ^1H NMR and FT-IR. These results suggested the formation of an amide linkage between the amino groups of chitosan and the carboxyl groups of oleic acid. The viscosity of O-chitosan sharply increased with the increase of concentration, whereas that of unmodified chitosan rose only slightly. This increase became larger as the DS increased. All of the O-chitosans could reduce surface tension slightly. The critical aggregation concentration （CAC） of O-chitosans with DS 5%, 11%, and 27% were 79.43 mgL^-1, 31.6 mgL^-1, and 10mgL^-1, respectively. Nanoparticles were prepared using an O/W emulsification method. The mean diameters of the polymeric amphiphilic nanoparticles of O-chitosans with DS 5% and 11% were around 327.4 nm and 275.3 nm, respectively.

关 键 词：O-chitosan VISCOSITY surface tension fluorescence NANOPARTICLES 

分 类 号：O62[理学—有机化学]