急性脑梗死患者血浆D-二聚体水平的临床研究  

Clinical research of plasma D-dimer in patients with acute cerebral infarction

作　　者：赵鸿平[1] 

机构地区：[1]山西医科大学第二医院神经内科,太原030001

出　　处：《检验医学与临床》2008年第9期527-528,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨血浆D-二聚体在急性脑梗死发病过程中的变化。方法采用免疫比浊法检测30例健康对照者及46例急性脑梗死患者(入院后第1、7、14天)血浆D-二聚体的变化,分析其与梗死体积大小、神经功能缺损程度的相关性。结果急性脑梗死组患者血浆中D-二聚体含量与健康对照组相比明显增高(P<0.01),大、中体积梗死组及神经功能缺损重、中型组的D-二聚体水平明显高于小体积梗死组及神经功能缺损轻型组(P<0.01)。结论急性脑梗死患者血浆D-二聚体水平可作为判断病情的客观指标。Objective To explore the fluctuation of plasma D-dimer and its clinical significance in acute cerebral infarction. Methods 30 healthy people （control group） and 46 patients with acute cerebral infarction （cerebral infarction group, on day 1, 7 and 14 after admission） were enrolled in the investigation. Immunoturbidimetry was applied to measuring plasma D-dimer. The correlation of plasma D-dimer with infarction area and neurologic impairment degree was analyzed. Results The content of plasma D-dimer was much higher in cerebral infarction group than that of control group （P〈0.01）. Compared with that of small area infarction group and mild neurologic impairment group, the content of plasma D-dimer was much higher in large and moderate area infarction group as well as severe neurologic impairment group（P〈0.01）. Conclusion The level of plasma D-dimer can be used as the objective index of evaluating the state of acute cerebral infarction.

关 键 词：脑梗死 D-二聚体 免疫比浊法 

分 类 号：R446.1[医药卫生—诊断学] R743.33[医药卫生—临床医学]