蛋白激酶C在中性粒细胞凋亡信号转导中的作用  

Role of protein kinase C in the regulation of apoptotic signal transduction of human neutrophils

作　　者：李国利[1] 刘佳佳[1] 

机构地区：[1]泸州医学院分子生物学实验室

出　　处：《国际免疫学杂志》2008年第3期179-182,共4页International Journal of Immunology

基　　金：基金项目：国家自然科学基金资助项目（30371305）

摘　　要：蛋白激酶C（PKC）是一类Ca^2＋、磷脂依赖性的丝氨酸／苏氨酸蛋白激酶，由12种具有不同生物学特性的同工酶组成。PKC通过催化多种蛋白质上Ser／Thr的磷酸化，在细胞下游信号转导和调节细胞功能中发挥重要的作用。中性粒细胞（PMN）是参与机体固有免疫的主要细胞，一旦分化成熟便启动它的自发性凋亡程序，从而维持机体的内环境稳定和促成炎症反应的无损伤性收敛。PMN凋亡的调控是一个受多基因、多因子、多条信号转导通路独立或交联作用的复杂网络。作为细胞内信号转导重要递质的PKC，在调控PMN的自发性凋亡进程中起着重要作用。Protein kinase C （PKC） , a calcium ion and phospholipid dependent serine/threonine protein ki- nase, is composed of twelve isoenzymes with different biologic characteristics. PKC plays a key role in down-stream signaling and cell functions by catalyzing Ser/Thr phosphorylation in proteins. Polymorphonuclear neutrophils （PMNs）are primary cells involved in innate immunity. Once differentiate , PMNs undergo spon- taneous apoptosis program. This process has been recognized as a crucial mechanism for maintaining the stability of internal environment and accomplishing the resolution of inflammation. The regulation of neutrophll apoptosis is a complicated network by many genes, cytokine and multiple independent or crosslinked signa- ling pathways. As an important intracellular signaling transmitter, PKC exerts a marked role in spontaneous apoptosis of neutrophils.

关 键 词：PKC 中性粒细胞 凋亡 信号转导 

分 类 号：R285.5[医药卫生—中药学]