细胞衰老的研究进展  

The research progress on cell senescence

作　　者：马树宝[1] 霍金龙[1] 曾养志(审校)[2] 

机构地区：[1]云南农业大学云南省版纳微型猪近交系重点实验室云南农业大学动物科学学院,云南昆明650201 [2]云南农业大学云南省版纳微型猪近交系熏点实验室,云南农业大学动物科学学院

出　　处：《国际免疫学杂志》2008年第3期183-187,共5页International Journal of Immunology

基　　金：基金项目：国家863重点资助项目（2003AA205009）

摘　　要：细胞衰老的关键特征是经长期正常生长后停止生长，并伴随着一系列功能上和形态学上的变化，但仍保持代谢功能。根据不同的诱导机制，细胞衰老分为复制衰老和应激诱导衰老两类。随着细胞衰老的深入研究，产生了多种学说，其中自由基学说、端粒学说研究得较为深入。p16^INK4a／Rb，p19^ABF／p53／p21^Cipl是引发细胞衰老的两条重要通路，它们相互作用，但当所涉及的关键调节因子发生突变时，细胞将延缓衰老或绕过衰老程序继续增殖。The key characteristic of cell senescence is the growth stop after long life, with a series of changes in functions and morphology. Howewer, the cell still keep the function in metabolism. Cell senescence is divided to replicative senescence and stress-inducing senescence according to the different inducing mechanism. Many theories were established with the progress of study, such as free radical theory and telomere theory. 16^INK4a/Rb and p19^ARF/p53/p21^Gipl, are important signal pathways in the process of cell senescence. The two pathways interacted with each other closely. If the key regulators mutated, cells would defer or avoid senescence and keep on proliferating.

关 键 词：细胞衰老 自由基 线粒体 端粒 

分 类 号：Q[生物学]