血清髓鞘碱性蛋白在糖尿病周围神经病变中的临床意义  

Clinical value of myelin basic protein level on diagnosis of peripheral neuropathy

作　　者：廖斌[1] 秦爱平[1] 王芳[1] 

机构地区：[1]湖南省马王堆医院内分泌科,湖南长沙410016

出　　处：《心血管康复医学杂志》2008年第2期110-112,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：湖南省卫生厅科研基金资助项目(编号B2005128)

摘　　要：目的:探讨测定血清髓鞘碱性蛋白在糖尿病周围神经病变诊断中的价值。方法:用放免法分别测定93例糖尿病患者(包括无神经病变组45例,神经病变组48例)和50例健康人血清髓鞘碱性蛋白(MBP)含量,并相互对比。周围神经病变组分为病情轻组和病情重组,比较其MBP水平。结果:糖尿病有神经病变组和无神经病变组及正常对照组的MBP含量分别为(7.224±0.772)μg/L、(2.115±0.633)μg/L、(1.008±0.244)μg/L,组间比较P均<0.001;糖尿病有神经病变组和无神经病变组MBP水平与空腹血糖、餐后血糖及糖化血红蛋白水平之间均无相关性;糖尿病周围神经病变病情轻组和病情重组MBP水平分别为(5.443±0.221)μg/L,(8.376±0.162)μg/L(P<0.01)。结论:MBP水平在糖尿病周围神经病变的诊断中有一定的价值,可作为糖尿病周围神经病变病情及疗效评价的良好指标。Objective： To investigate the clinical value of serum myelin basic protein （MBP） level on diagnosis of diabetic peripheral neuropathy. Methods： Using radioimmunoassay to measure and compare MBP content of 93 patients with diabetic mellitus （no peripheral neuropathy group constructed from 45 cases, peripheral neuropathy group constructed from 48 cases） and 50 normal controls. Peripheral neuropathy group was divided into two groups （light de- gree group and heavy degree group） according the pathogenetic condition. Results： MBP level of diabetic peripheral neuropathy, no peripheral neutopathy group and normal control group respectively were （7. 224±0. 772） μg/L, （2. 115±0. 633） μg/L, （1. 008±0. 244） μg/L （P〈0. 001, among three groups） and the MBP levels of diabetic peripheral neuropathy group and noperipheral neuropathy group had no relate with fasting blood sugar, post cibum blood sugar and Hbalc levels. The MBP levels of light degree group and heavy group of pathogenetic condition were （5. 443±0. 221） μg/L, （8. 376±0. 162） μg/L （P〈0. 01）. Conclusion： MBP is valuable in diagnosing diabetic peripheral neuropathy and it can be used to evaluate patient＇s condition and treatment effect.

关 键 词：髓鞘碱性蛋白 糖尿病 糖尿病神经病变 

分 类 号：R587.109[医药卫生—内分泌]