大黄丹参对大鼠实验性SAP靶器官保护作用研究  

Dahuang Danshen on Improvement of Histology and Organic Function of Rats with Experimental Severe Acute Pancreatitis

作　　者：孙戴[1] 刘世宾[1] 许冠华[1] 罗静[1] 沈洁如[1] 李钢[2] 

机构地区：[1]浙江中医药大学,杭州310053 [2]杭州市中医院

出　　处：《浙江中西医结合杂志》2008年第5期273-275,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

基　　金：浙江省科技厅新苗人才计划项目资助课题(NO:2007G60G2120017)

摘　　要：目的:观察中药大黄、丹参注射液对重症急性胰腺炎大鼠治疗前后器官功能、胰腺组织的影响。方法:将实验大鼠分为正常组、模型组、大黄丹参组三组,以Aho’s胰胆管激活剂逆行注射法诱导大鼠重症急性胰腺炎模型。并于大黄、丹参注射液治疗后第24小时麻醉大鼠,抽血测血常规、肝肾功能,血清、腹水淀粉酶,进行大体解剖,观察胰腺病理组织学改变。结果:大黄丹参组血常规、肝肾功能,血清、腹水淀粉酶较模型组明显降低,胰腺间质水肿、充血和炎性细胞浸润较模型组减轻。结论:大黄、丹参联合应用可改善重症急性胰腺炎大鼠的胰腺组织和器官功能。Objective：To observe the effect of Dahuang Danshen on improvement of histology and organic function of rats with severe acute pancreastitis. Methods ： Experimental rats were divided into the normal group, the model group and the Dahuang Danshen group. Rat models with severe acute pancreastitis were induced by retrograde infusion of Ahog pancreas and bile duct activateor. After therapy by Dahuang Danshen for 24 hours, rat models were anaesthetic and the blood count, function of liver and kidney, blood serum and ascites amylase were measured. The pathologic histology of pancreas was observed after rat models were anatomized. Results ： The blood count, function of liver and kidney, blood serum and ascites amylase in the Dahuang Danshen group were obviously decreased compared with those in the model group. The pathologic observation showed the edema, hyperaemia and soakage of phlogistic cells in the Dahuang Danshen group were obviously lightened compared with those in the model group. Conclusion： Dahuang Danshen injection can improve the histology and organic function of rats with severe acute pancreastitis.

关 键 词：大鼠 重症急性胰腺炎 大黄 丹参注射液组织学 器官功能 

分 类 号：R285.5[医药卫生—中药学] R961[医药卫生—中医学]