三光气合成N-硝基-N,N'-二苯基脲的“一锅法”工艺  

The Synthesis of N-Nitro-N,N′-diphenyl Urea by One Pot Way Used Triphosgene as Acylating Agent

作　　者：许洪涛[1] 申晓霞[1] 曹丹[1] 李雪刚[1] 陈长水[1] 

机构地区：[1]华中农业大学理学院,湖北武汉430070

出　　处：《精细化工中间体》2008年第2期27-29,共3页Fine Chemical Intermediates

基　　金：国家自然科学基金资助项目(39770845)

摘　　要：以N-硝基-2,4,6-三氯苯胺为原料,三光气为酰化剂,一锅法合成N-硝基-N-(2,4,6-三氯苯基)-N′-3,5-二甲基苯基脲。并确定酰化反应的优惠条件为:甲苯作溶剂、三乙胺为催化剂、n(三光气)∶n(N-硝基-2,4,6-三氯苯胺,5)=0.36∶1,反相滴加,反应温度为20℃,反应时间2h,此条件下收率为80%左右。通过元素分析、红外光谱分析、核磁氢谱对产品进行了结构鉴定。The N＇-（3,5-dimethylphenyl）-N-nitro-N-（2,4,6-trichlorophenyl） urea were obtained by one pot way based on N-nitro-2,4,6-trichloroaniline used triphosgene as acylating agent. The synthesis technological conditions were discussed. The optimum reaction conditions were obtained as follows： touluene as solvent, triethylamine as catalyst, n （triphosgene） ：n（5）= 0.36.1, RP-dropping, temperature was 20℃, reaction time was 2 h, the yield was 80%. And the structures of the products were identified by elementary analysis, infra-red spectrum and nuclear magnetic resonance.

关 键 词：“一锅法” 三光气 N-硝基-N N'-二苯基脲 

分 类 号：TQ452[化学工程—农药化工]