单核细胞趋化蛋白-1与糖尿病心血管并发症的相关分析  

The correlation between MCP-1 and cardiovascular complication of diabetes

作　　者：刘凯[1] 陈爱华[1] 蔡德鸿[2] 吴芸[2] 罗婉莹[2] 

机构地区：[1]南方医科大学珠江医院心血管内科,广东广州510280 [2]南方医科大学珠江医院内分泌科

出　　处：《中国医师杂志》2008年第4期460-463,共4页Journal of Chinese Physician

基　　金：广东省科技项目计划资助项目（2006B36008004）

摘　　要：目的探讨单核细胞趋化蛋白-1（MCP-1）与糖尿病及其大血管并发症的关系。方法在社区常住人口中筛查出糖尿病患者65例，糖耐量受损患者64例，正常对照组60例，对上述人群经颈动脉超声检查颈内中膜厚度（IMT），根据其厚度判断是否合并动脉粥样硬化（AS），同时用夹心酶联免疫法检测单核细胞趋化蛋白-1（MCP-1），比较IGT合并AS，IGT无AS，DM合并AS，DM元，AS和正常对照组间MCP-1的关系。结果MCP-1正常对照组（12．00±9．33）pg／mL，IGT（20．47±18．23）pg／ml和DM（36．33±13．14）pg／ml，P=0．000；IGT合并AS（32．1±8．2）pg／ml高于IGT无AS[（15．7±8．7）pg／ml，P=0．007]，DM合并AS（43．5±8，8）pg／ml高于DM无AS[（28．3±12．8）pg／ml，P=0．014]。MCP-1与IMT呈正相关（r=0．307，P=0．001）。二分类logistic回归分析入选的变量为年龄，MCP-1，性别。结论单核细胞趋化蛋白-1与糖代谢异常和动脉粥样硬化关系密切，有可能成为未来治疗糖尿病和大血管并发症的靶点。Objective To explore the significance and correlation between MCP-1 and cardiovascular complication of diabetes. Methods 65 patients with diabetes and 64 patents with IGT and 60 healthy persons as control group are chosen from a population of 1231 residents at Jiangnan community in Guangzhou city. Ultrasonic inspection of carotid artery was applied to the intimae media thickness （ IMT）, and the levels of MCP-1 were detected by Elisa. Result There was significant difference in the levels of MCP-1 among the normal control group, IGT group and DM group （ P =0. 000）. The levels of MCP-1 in IGT complicated with AS patients were significantly higher than that in IGT alone patients. The levels of MCP-1 in DM complicated with AS patients were significantly higher than that in DM alone patients. The levels of MCP-1 were positively correlated with IMT in these patients. A forward LR Logistic regression analysis shoffed that IMT was a dependent variable, gender, MCP-1 and age are independently correlated with IMT. Conclusion MCP-1 is correlated with diabetes and its cardiovascular complication and it may be served as the target of therapy.

关 键 词：单核细胞化学吸引蛋白质1 糖尿病血管病变 患者 临床分析 

分 类 号：R587.2[医药卫生—内分泌] R54[医药卫生—内科学]