正交试验设计与灰色关联度分析用于熊果酸包合物载药量的影响因素研究  

Study on the Factors that Effected Loaded Dosage of Ursolic Acid Complex with Orthogonal Design and Gray Relation Analysis

作　　者：权鹏[1] 李瑞[1] 刘东飞[1] 徐群为[1] 

机构地区：[1]南京医科大学药学院,南京市210029

出　　处：《中国药房》2008年第13期973-974,共2页China Pharmacy

基　　金：江苏省天然药物研究与创制实验室开放课题(KF2005004);江苏省高校自然科学基础研究面上项目(07KJD350152);南京医科大学科技发展基金重点项目(2005NYDZD12)

摘　　要：目的:比较灰色关联度分析与正交试验极差分析在数据处理结果方面的替代性。方法:以影响熊果酸包合物载药量的4个因素即主客分子摩尔比、搅拌时间、搅拌速度和包合温度为例进行分析。结果:2种方法对数据分析结果相似,主客分子摩尔比和包合温度均为影响较大的因素。结论:在试验数据不能满足正交试验极差分析时,可采用灰色关联度分析方法对数据进行分析和处理。OBJECTIVE：To compare the substitution between the gray relation analysis（GRA） and the orthogonal design （OD） in data processing . METHODS：Take the four factors including the molar ration of drug and cyclodextrins, the agitating time and speed, and the temperature of complexation that influenced on loaded dosage of ursolic acid complex as example to analysis with 2 kinds of methods. RESULT：The result of analysis was similar by 2 kinds of methods , the molar ration of drug and the temperature of complexation were the major influence factors. CONCLUSION：When the data cannot fit to the analysis of range of OD,GRA can be used to it .

关 键 词：熊果酸 环糊精 包合物 正交试验设计 灰色关联度分析 

分 类 号：R917[医药卫生—药物分析学]