1129例疑诊过敏性接触性皮炎患者斑贴试验分析  

Patch test results in 1129 patients with suspected allergic contact dermatitis

作　　者：米霞[1] 葛萍[1] 袁湘军[1] 李恒进[1] 

机构地区：[1]解放军总医院皮肤科,北京100853

出　　处：《军医进修学院学报》2008年第2期109-111,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的：分析解放军总医院皮肤科2005年7月～2006年7月1129例疑诊过敏性接触性皮炎（ACD）患者斑贴试验结果，明确临床常见变应原及各种变应原和性别的关系，为本地区ACD的防治及斑贴试验变应原的选择提供依据。方法：用改良的欧洲标准变应原系列对疑诊ACD患者进行斑贴试验，并对结果作统计学处理。结果：1129例受试者中，阳性反应747例，阳性反应率较高的变应原依次是：硫酸镍、硫柳汞、重铬酸钾、芳香混合物、甲醛，阳性反应率较低的变应原有：秋兰姆混合物、硫氢基混合物、咪唑烷基尿素、溴硝丙二醇。女性患者对硫酸镍的阳性反应比男性患者高，而男性患者对卡巴混合物的阳性反应比女性患者高，其差异有统计学意义（P〈0．001）。结论：硫酸镍、硫柳汞、重铬酸钾、芳香混合物、甲醛是本地区ACD的常见变应原。男女患者对硫酸镍和卡巴混合物的反应存在差异。斑贴试验用于寻找ACD患者的可疑致病原因安全有效。Objective： To study more frequent sensitizers and relationship between sex and allergens by analyzing results of patch testing 1,129 suspected allergic contact dermatitis （ACD） patients in department of Dermatology in PLA General Hospital from July 2005 to July 2006, and to provide a clue for prevention and cure for ACD and selection of allergens used in diagnosis in the area. Methods： Suspected ACD patients were patch tested with a modified European standard series of allergens. Results： Among 1129 patients, 747 had positive patch test reactions. Nickel sulfate was the most frequent sensitizer, followed by Thimerosal, Potassium dichromate, Fragrance mix and Formaldehyde. Frequencies of contact allergy to Thiuram mix, Mereapto mix, Imidazolidinyl urea, and bronopol were relatively low. Positive reactions to nickel sulfate were more frequently observed among women. Men had a higher frequency of positive reactions to Carba mix. The difference in nickel and Carba mix sensitization rates between women and men was statistically significant （ P 〈0.001 ）. Conclusion： Nickel sulfate, Thimerosal （merthiolate ）, Potassium dichromate, Fragrance mix and Formaldehyde are more frequent sensitizers in the area. Reactions to nickel sulfate and Carba mix are different between men and women, it is effective and safe to patch test suspected ACD patients.

关 键 词：斑贴试验 皮炎 变应性接触性 变应原 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]