苦参碱防治放射性肺损伤的实验观察  

Effect of matrine on radiation-induced pneumonitis in mice

作　　者：孟玲玲[1] 冯林春[1] 石怀银[2] 马林[1] 陈华[3] 杨东[1] 欧光明[1] 陈新静[1] 崔迪[1] 

机构地区：[1]解放军总医院放疗科,北京100853 [2]解放军总医院病理科,北京100853 [3]解放军总医院动物中心,北京100853

出　　处：《军医进修学院学报》2008年第2期134-136,共3页Academic Journal of Pla Postgraduate Medical School

基　　金：解放军总医院苗圃基金2006年度立项资助项目(06MP71)

摘　　要：目的:探讨苦参碱对放射性肺损伤的防治作用。方法:44只昆明(KM)小鼠随机分为4个组:单纯照射(RT)组、照射+苦参碱(MRT)组、照射+丹参(DRT)组、照射+川芎嗪(TRT)组。用6MV-X线单次照射小鼠右肺30Gy,给药组在照射前2 d开始腹腔给药,直到各个观察点结束。取右肺中叶大体观察后制作常规切片,HE染色后显微镜下观察肺组织变化。结果:MRT组肺组织充血水肿、炎细胞浸润、上皮细胞和间质细胞增生等炎性反应明显轻于其它3组。MRT组的红细胞密度计数及有核细胞密度计数均小于其它3组,且当照射2个月时差异性更明显(P<0.01);DRT组及TRT组的红细胞密度计数及有核细胞密度计数均小于RT组,但3组间的差异没有统计学意义(P>0.05)。结论:苦参碱能减轻小鼠急性放射性肺损伤,且其防护作用优于丹参和川芎嗪。Objective： To observe the protective effect of matrine on radiation pneumonitis in mice. Methods： 44 mice were divided randomly into four groups： radiation alone （RT） ,radiation plus matrine （MRT）, radiation pins danshen insection, radiation plus tetramethylpyrazine. The right lungs of the mice were irradiated with 6MV-X ray, the radiation dose was 30Gy. The peritoneal cavity infusion was began 2 days before radiation for the medication groups until every observation point ended. The middle leaves of the right lungs were observed in general and studied by light-microscope after HE dyeing. Results： The radiation pneumonitis in MRT-group was lighter than the other three groups. The density of red blood cells and the density of karyotes of MRT-group were smaller than the other groups. The discrepancy was more obvious 2 moths after radiation （ P 〈 0. 01 ）. Conclusion： Matrine can lessen radiation pneumonitis in mice, and its protective effectiveness is better than danshen insection and tetramethylpyrazine.

关 键 词：辐射性肺炎 苦参碱 丹参注射液 川芎嗪 治疗结果 

分 类 号：R563.19[医药卫生—呼吸系统]