水泥粉尘接触工人血清中一氧化氮及一氧化氮合酶水平研究  

Study on nitric oxide and nitric oxide synthase levels in serum of workers exposed to cement dust

作　　者：陈丽[1] 李胜联[1] 施文祥[1] 邓曼玲[2] 

机构地区：[1]桂林医学院预防医学教研室,广西桂林541001 [2]桂林市疾病预防控制中心,541001

出　　处：《中国职业医学》2008年第2期115-116,共2页China Occupational Medicine

基　　金：广西科技厅自然科学基金项目(编号:桂科自0640184)

摘　　要：目的探讨水泥粉尘接触工人血清中一氧化氮(NO)及一氧化氮合酶(NOS)水平的变化。方法采用硝酸还原酶法,对50名实验组及50名正常对照者的血清NO及NOS水平进行测定。结果实验组工人血清NO水平高于对照组,实验组总NOS和诱导型NOS(iNOS)的酶活力明显高于对照组,两组间差异有显著性(P<0.05);不同工龄组工人NO、总NOS、iNOS水平经t’检验,差异均无显著性(P>0.05)。结论NO及NOS与水泥粉尘所致的病理损伤有关。Objective To investigate the changes of nitric oxide （NO） and nitric oxide synthases （NOS） levels in serum of workers exposed to cement dust. Methods Nitrate reductate was used to detect serum NO and NOS levels in 50 workers exposed to cement dust and 50 normal controls. Results The results revealed that NO and NOS levels in dust exposure workers were significantly higher than those of the normal control groups （P 〈 0.05 ） ; it showed no significant difference among the NO, NOS and iNOS levels in dust exposure workers from different groups（P 〉0.05）. Conclusion The study indicates that NO and NOS might be associated with pathological damage caused by cement dust.

关 键 词：水泥粉尘 一氧化氮 一氧化氮合酶 

分 类 号：R135.2[医药卫生—劳动卫生]