医院感染脑膜炎败血性金黄杆菌的分布及耐药性分析  

The distribution and drug resistance of hospital infected Chryseobacterium meningosepticum

作　　者：周战修[1] 袁明军[1] 

机构地区：[1]济宁医学院附属金乡医院,山东272200

出　　处：《国际检验医学杂志》2008年第4期314-314,317,共2页International Journal of Laboratory Medicine

摘　　要：目的了解我院脑膜炎败血性金黄杆菌的分布和耐药性。方法统计分析我院近5年来分离的73株脑膜炎败血性金黄杆菌的耐药情况;用双纸片协同试验筛选金属β-内酰胺酶。结果脑膜炎败血性金黄杆菌产金属β-内酰胺酶为37.0%,主要分布在重症监护(ICU)病房,哌拉西林/他唑巴坦、万古霉素和利福平耐药率较低,分别为45.2%、40.6%和28.5%。结论脑膜炎败血性金黄杆菌表现为多重耐药,临床医师应根据药敏试验合理选择抗菌药物。Objective To investigate the distribution and drug resistance of Chryseobacterium meningosepticum （CM） in our hospital. Methods The status of drug resistance of 73 strains of CM isolated from our hospital in the past 5 years was statistically analyzed. Metallo-β-lactamase producing isolates were screened by double-disk synergy test. Results The rate of metallo-β-lactamase producing Chryseobacterium meningosepticum （CM） accounted for 37.0%, which mainly distributed at intensive care unit （ICU）. The resistant rates of CM clinical isolates to piperacillin/tazobactam, vancomycin and levofloxacin were 45.2%, 40.6% and 28.5%, respectively. Conclusion CM displays multi-resistance to antibiotics. Antimicrobial agents should be selected rationally by clinicians according to antimicrobial susceptibility test results.

关 键 词：金黄杆菌属 抗药性 细菌 Β内酰胺酶类 

分 类 号：R446.5[医药卫生—诊断学]