蒲葵子的体外抗癌活性  

Anti-Tumor Activity of the Extracts of Livistona chinesis in vitro

作　　者：陈艳[1] 林新华[1] 李少光[1] 翁绳美[1] 姚宏[1] 

机构地区：[1]福建医科大学药学院,福州350004

出　　处：《福建医科大学学报》2008年第2期93-95,共3页Journal of Fujian Medical University

基　　金：国家自然科学基金资助项目(20675015);福建省教育厅资助省属高校项目(2005K049);福建省教育厅科研基金资助项目(JA07101)

摘　　要：目的研究蒲葵子提取物的各萃取部位体外抗肿瘤作用。方法采用四甲基偶氮唑盐(MTT法)比色法,观察蒲葵子提取物的各萃取部位对肝癌细胞HepG2和白血病细胞HL60增殖的抑制作用。结果蒲葵子提取物的各萃取部位在体外对肝癌细胞HepG2和白血病细胞HL60有明显的抑制作用,正丁醇部位的半数抑制率分别为7.94和10.72,效果最为显著。结论蒲葵子提取物的各萃取部位能抑制肝癌细胞HepG2和白血病细胞HL60的增殖,有较强的体外抗肿瘤活性。Objective To investigate anti-tumor effect of the extracts of Livistona chinesis in vitro. Methods The cytotoxic effects of the four kind extracts of Livistona chinesis on two tumor cell lines cultured in vitro were tested by MTT assay. The tumor cell lines were HepG2 and HL60. Results The extracts of Livistona chinesis induced significant growth arrested in two malignant tumor cell lines which cultured in vitro. IC50 of these cells exposed to the extracts from N-butanol for 48 hours approach 7.94% and 10.72%. Conclusion The N-butanol extracts of Livistona chinesis had obvious anti-tumor activity in vitro.

关 键 词：棕榈科 抗肿瘤药 提取法 

分 类 号：R285[医药卫生—中药学]