盆底器官脱垂患者盆底肌α-肌动蛋白的表达及意义  

Change of α-Actin Expression in Levator Ani Muscle of Pelvic Organ Prolapse

作　　者：江絮萍[1] 宋岩峰[1] 

机构地区：[1]南方医科大学教学南京军区福州总医院妇产科,福州350025

出　　处：《福建医科大学学报》2008年第2期125-126,146,共3页Journal of Fujian Medical University

基　　金：福建省科技攻关重点项目(2003Y016)

摘　　要：目的探讨盆底肌α-肌动蛋白含量及其与盆底组织膨出(POP)发病的关系。方法POP患者(POP组)20例及无POP的直肠癌患者(对照组)30例行盆底肌活检,光镜及电子显微镜观察盆底肌形态,免疫组织化学检测肌细胞内α-肌动蛋白的表达。结果POP组α-肌动蛋白含量较对照组少,差别有统计学意义(P<0.05)。结论α-肌动蛋白表达减少可能造成盆底组织松弛、支持能力减弱,与POP的发生密切相关。Objective To investigate the a-actin status in pelvic organ muscle, to detect the alteration of collagen ultrastructure in pelvic organ muscle and to explore whether the alteration can contribute to pelvic organ prolapse（POP）. Methods The samples were obtained from 20 subjects of POP and 20 subjects of I a- I b cervical cancer in operation. The change of a-actin filament was examined by immu- nocytochemistry. Results The mean concentration of a-actin was significantly lower in the patients with POP （0.22±0.03）, compared to the control（1.13±0.12, P〈0.01）. Conclusion The disarrngment of the actin filament in the levator ani muscle may contribute to pelvic organ prolapse.

关 键 词：内脏下垂 肌动蛋白类 子宫脱垂 骨盆底 免疫组织化学 

分 类 号：R711.2[医药卫生—妇产科学]