胰岛素治疗与早期糖尿病性黄斑水肿进展的关系  

The consequence of early diabetic macular edema after intensive insulin therapy

作　　者：王宁[1] 许迅[1] 朱剑锋[1] 姚莉莉[1] 蒋筠[1] 

机构地区：[1]上海交通大学附属第一人民医院眼科,200080

出　　处：《眼科》2008年第1期56-58,共3页Ophthalmology in China

摘　　要：目的观察首次进行单纯胰岛素治疗的2型糖尿病患者黄斑厚度的改变情况。设计前瞻性病例系列。研究对象34例单纯胰岛素治疗糖尿病患者。方法对上海交通大学附属第一人民医院内分泌科的34例糖尿病患者首次进行重组人胰岛素控制血糖,用相干光断层扫描(OCT)检查治疗前及治疗后3个月血糖在正常范围时的黄斑区图像改变。主要指标黄斑中心凹厚度。结果68眼在进行胰岛素治疗前、治疗后黄斑中心凹厚度分别平均为(195.07±27.75)μm、(198.5±27.72)μm(t=1.9960,P= 0.1569)。胰岛素治疗后25眼黄斑中心凹厚度有所增加。结论单纯胰岛素控制血糖治疗糖尿病性黄斑病变3个月内无明显疗效;临床上仍需密切随访,必要时联合药物、激光等治疗方法。(眼科,2008,17:56-58)Objective To access the macular status of type 2 diabetes mellitus after first time insulin treatment, and analyse the changes of macular thickness. Design Prospective case series. Participants 34 diabetes patients （68 eyes） treated with insulin for the first time. Methords The diabetes patients were treated with intensive Humulin NPH for 3 months. Optical coherence tomography were performed in each eye before and after the treatment. Main Outcome Measures Thickness of macular foveal. Results The thickness of macular foveal was （195.07±27.75） μm before the treatment of insulin, and （198.57±27.72）μm after 3 months of insulin therapy （t= 1.9960, P=0.1569）. 25 eyes had macular thickening after insulin therapy. Conclution There is no obvious therapeutic effect only to control blood glucose using insulin within 3months in patients with diabetic macular edema, which needs close following-up and other treatment options in time.

关 键 词：胰岛素 糖尿病黄斑水肿 体层摄影术 光学相干 

分 类 号：R587.2[医药卫生—内分泌] R587.1[医药卫生—内科学]