微波法合成马来酸酐酰化壳聚糖  

Synthesis of N-maleoyl chitosan by microwave method

作　　者：舒红英[1] 唐星华[1] 童永芬[1] 吴雪敏[1] 

机构地区：[1]南昌航空大学,江西南昌330063

出　　处：《南昌航空大学学报（自然科学版）》2008年第1期63-66,共4页Journal of Nanchang Hangkong University(Natural Sciences)

摘　　要：采用微波辐射,以N,N-二甲基甲酰胺为反应介质,合成了马来酸酐酰化壳聚糖。利用单因素实验和正交实验设计考察了反应投料摩尔比、微波辐射功率、微波辐射时间和反应温度等因素对取代度的影响。结果表明:最佳合成条件为马来酸酐与壳聚糖的投料摩尔比为1.5∶1,微波功率为600w,反应温度为110℃,反应时间为25min。并根据IR图中的特征吸收峰和UV谱图中强吸收波长变化验证了产物结构,且通过元素分析证实了马来酸酐改性壳聚糖成功。With the N and N - dimethylformamide as reaction medium, N - maleoyl chitosan was synthesized by microwave irradiation. Effects of the mole ratio of maleic anhydride to chitosan, microwave power,microwave irradiation time and reaction temperature on the degree of substitution were investigated by using single factor experimentation and orthogonal experimental design. The optimal condition for the reaction of N -maleoyl chitosan by microwave is; the microwave power （600w）, the temperature （110℃）, the time （25min） and the mole ratio of maleic anhydride to chitosan （1. 5：1 ）. The characteristic absorption bands in IR and the change of the strong absorption bands in UV both show the structure of N - acyl chitosan. The study of elemental analysis confirms that maleic anhydride successfully modifies the chitosan.

关 键 词：微波 壳聚糖改性 马来酸酐 酰化反应 

分 类 号：O636.1[理学—高分子化学]