LP(a)、Hcy、HS-CRP联合检测在老年下肢动脉粥样硬化中的临床意义  

Significance of determination of lipoprotein(a)、homocysteine and high-sensitivity C-reactive protein in elderly atherosclerosis of the lower extremities

作　　者：刘翠平[1] 罗艳丽[1] 刘素霞[1] 

机构地区：[1]河北医科大学第三医院干部病房,石家庄市050051

出　　处：《河北医药》2008年第4期436-437,共2页Hebei Medical Journal

摘　　要：目的根据老年下肢动脉粥样硬化患者血脂蛋白(a)[LP(a)]、同型半胱氨酸(Hcy)和高敏C反应蛋白(HS-CRP)的变化,探讨其联合检测对指导临床治疗的意义。方法选择彩色超声确诊有下肢动脉粥样硬化的老年患者56例作为研究组,测定血脂、同型半胱氨酸、高敏C反应蛋白,并与同期住院、彩色超声除外下肢动脉粥样硬化且其他条件相匹配的20例老年人进行对照研究。结果老年下肢动脉粥样硬化患者血脂蛋白(a)、Hcy、HS-CRP均明显高于对照组,有动脉粥样硬化斑块的亚组血HS-CRP明显高于非斑块组,差异有统计学意义(P<0.05)。结论脂代谢紊乱、同型半胱氨酸代谢异常、炎症反应均与老年人下肢动脉粥样硬化形成有关,粥样斑块患者炎症反应更明显,提示临床三者应同时干预,粥样斑块患者应强化抗炎治疗。Objective To study the clinical significance of the changes of plasma hpoprotein [ LP （a）], homoeysteine（Hcy） and high-sensitivity C-reactive protein（HS-CRP） in elder patients with atheroselerosis of the lower extremities. Methods All patients were examined by color Doppler ultrasound. 56 cases of lower extremitical atheroselerosis were selected as the research group and divided into 2 subgroups based on the atherosclerotic plaques. 20 eases without lower extremitical atherosclerosis were selected as control group. The average age of research group and control group were （74 ± 9）, （72 ± 8） respectively. LP（a） ,Hcy and HS-CRP of all cases were detected. Results There was a significant increase in levels of LP（a）,Hcy and HS-CRP in all the patients with atherosclerosis compared with that of control group （ P 〈 0.05）. The patients with atherosclemtic plaques have higer Hcy level than that of the patients without atherosclerotic plaques. Conclusion LP（a） ,Hey and HS-CRP contribute to the development of lower extremitical atherosclerosis. There are utilitarian clinical value of their detection, especially the measurement of HS-CRP.

关 键 词：动脉粥样硬化 血脂蛋白(a) 同型半胱氨酸 高敏C反应蛋白 老年人 

分 类 号：R587.104[医药卫生—内分泌] R541.4[医药卫生—内科学]