转录激活因子3、葡萄糖转运蛋白-1、增殖细胞核抗原在尖锐湿疣组织中的表达  

Expression of Star 3, GluT-1 and PCNA in condylomata acuminata

作　　者：尹光文[1] 蔡丙杰[1] 李敏[1] 张守民[2] 姚亚琼[1] 

机构地区：[1]郑州大学第一附属医院皮肤科,450052 [2]河南省人民医院皮肤科

出　　处：《中华皮肤科杂志》2008年第5期301-303,共3页Chinese Journal of Dermatology

摘　　要：目的探讨尖锐湿疣组织中转录激活因子（Stat）3、葡萄糖转运蛋白-1（GluT-1）、增殖细胞核抗原（PCNA）的表达及意义。方法采用免疫组化SP法检测40例尖锐湿疣组织中Stat3、GluT-1和PCNA的表达。结果尖锐湿疣组织中Stat3、GluT-1和PCNA阳性表达率分别为85．0％（34／40）、87．5％（35／40）和85．0％（34／40），正常人对照组分别为35．0％（7／20）、30．0％（6／20）和55．0％（11／20）；尖锐湿疣组织中Stat3、GluT-1和PCNA阳性表达强度多为＋＋～＋＋＋，正常人对照组多在-～＋＋。尖锐湿疣组和对照组中Stat3、GluT-1和PCNA阳性表达率及表达强度差异均有统计学意义（P〈0．05）。尖锐湿疣组织中PCNA与Stat3和GluT-1表达强度间存在正相关性（P〈0．05），Stat3与GluT-1表达呈正相关（P〈0．05）。结论尖锐湿疣组织中存在Stat3、GluT—1和PCNA过表达，Stat3和GluT-1的过表达可能与尖锐湿疣组织的过度增殖有关。Objective To explore the expression and significance of signal transducer and activator of transcription 3 （Stat 3 ）, glucose transporter protein 1 （GluT-1） and proliferation cell nuclear antigen （PC NA） in lesions of condylomata acuminata （CA）. Methods SP immunohistochemistry method was used to measure the expression of Stat 3, GluT-1 and PCNA in tissue samples from 40 cases of CA and 20 normal skin controls. Results The positivity rates of Stat 3, GluT-1 and PCNA were 85.0% （34/40）, 87.5% （35/40） and 85.0%（34/40）, respectively in CA tissue, 35.0% （7/20）, 30.0% （6/20）and 55.0% （11/20）, respectively in the control tissue; statistical difference was observed in these rates between the two groups （all P 〈 0.05 ）. The expression intensity of Stat 3, GluT-1 and PCNA was also higher in CA tissue than that in the controls. In addition, the expression intensity of PCNA was correlated with that of Stat 3 and GluT-1 in CA tissue （both P 〈 0.05 ）. Conclusions There is an overexpression of Stat 3, GluT-1 and PCNA in CA tissue, and the overexpression of Stat 3 and GluT-1 may be associated with the over-proliferation of CA tissue.

关 键 词：尖锐湿疣 STAT 3转录因子 葡萄糖转运体1型 增殖细胞核抗原 

分 类 号：R752.53[医药卫生—皮肤病学与性病学] R392.11[医药卫生—临床医学]