氟比洛芬酯复合芬太尼用于食管癌术后静脉自控镇痛的临床观察  

Evaluation of flurbiprofen axetil with fentanyl for postoperative patient-controlled intravenous analgesia in patients underwent resection of esophageal carcinoma

作　　者：冯艳平[1] 李廷坤[1] 卢锡华[1] 章云飞[1] 王根生[1] 吕帅国[1] 

机构地区：[1]河南省肿瘤医院麻醉科,郑州市450003

出　　处：《临床麻醉学杂志》2008年第4期295-296,共2页Journal of Clinical Anesthesiology

基　　金：河南省科技攻关项目(0611043900)

摘　　要：目的观察氟比洛芬酯用于食管癌术后静脉自控镇痛(PCIA)的效果和安全性。方法ASAⅠ或Ⅱ级食管癌根治术患者60例,随机均分为三组,术后PCIA芬太尼1·0mg、氟哌利多2·5mg组(A组);术后PCIA芬太尼0·5mg、氟比洛芬酯100mg、氟哌利多2·5mg组(B组);麻醉前静注氟比洛芬酯50mg,术后PCIA芬太尼0·5mg、氟比洛芬酯50mg、氟哌利多2·5mg组(C组),镇痛药均用生理盐水稀释至100ml。记录术后1、2、4、8、12、24、36、48h的镇痛评分(VAS)、Ramsay镇静评分、PCIA按压次数及不良反应。结果术后PCIA按压次数与各时点的VAS三组间差异均无统计学意义。B、C组Ramsay镇静评分及恶心、呕吐发生率低于A组(P<0·05)。结论氟比洛芬酯复合芬太尼用于食管癌根治术术后静脉自控镇痛的效果良好,且能减少芬太尼用量,同时降低不良反应的发生。Objective To evaluate the efficacy and safety of flurbiprofen axetil combined with fentanyl for postoperative patient-controlled intravenous analgesia （PCIA）in patients underwent resection of esophageal carcinoma. Methods Sixty ASA class Ⅰ or Ⅱ patients were divided equally and randomly into three groups of fentanyl 1.0 mg＋droperidol 2.5 rag（group A）,fentanyl 0.5 mg＋ flurbiprofen axetil 100 mg＋droperidol 2.5 mg （group B） and fentanyl 0.5 mg＋flurbiprofen axetil 50 mg＋droperidol 2.5 mg and additionally injected with intravenous flurbiprofen axtil 50 mg prior to the surgery （group C）. The VAS, Ramsay sedation scale, PCIA pressing times and the adverse effects were recorded at 1,2,4,8,12,24,36,48 h after surgery. Results Patients in the three groups did not show significant difference in the VAS and PCIA pressing times. Ramsay sedation scale,the incidence rate of adverse events such as nausea and vomiting in group A were significantly higher than those in group B and C. Conclusion Co-administration of flurbiprofen axetil with fentanyl by PCIA offers overall favorable analgesic responses as well as the reduction of fentanyl consumption during PCIA in the patients following esophageal carcinoma surgery.

关 键 词：氟比洛芬酯 芬太尼 患者静脉自控镇痛 

分 类 号：R614[医药卫生—麻醉学]