三种他汀类药物对角叉菜胶致大鼠气囊滑膜炎组织中肿瘤坏死因子-α表达的影响  

Effects of three stains on the expression of tumor necrosis fator-alpha in carrageenan -induced synovitis in Rats

作　　者：赵征[1] 王炎焱[1] 黄烽[1] 任建平[1] 

机构地区：[1]解放军总医院风湿科,北京100853

出　　处：《中华风湿病学杂志》2008年第5期329-332,I0002,共5页Chinese Journal of Rheumatology

摘　　要：目的研究他汀类药物的抗炎机制。方法用苏木素-伊红（HE）染色方法检测他汀类药物对角叉菜胶致大鼠背部气囊滑膜炎模型皮肤组织中炎性细胞的影响，用免疫组织化学SP法检测大鼠背部气囊滑膜炎模型皮肤组织中肿瘤坏死因子（TNF）-α的表达。结果HE染色结果显示他汀类药物能显著抑制急性炎症反应，并降低大鼠背部气囊滑膜炎模型皮肤组织中TNF—α的表达。结论他汀类药物具有较强的抗炎作用。Objective To explore the anti-inflammatory mechanisms of three stains. Methods Airpouch induced acute inflammation rat model was developed by subcutaneous injection of carrageenan. Inflammatory invasion and tumor necrosis fator-alpha （TNF-α） expression levels of the inflammed skins were examined by immunohistochemical methods and digital image analysis. The anti-inflammatory action of the 3 different statins was compared. Results Stains could inhibit inflammatory invasion and the expression of TNF-α. Conclusion The statins have demonstrated strong inhibition of inflammation.

关 键 词：他汀类药物 苏木素伊红染色 肿瘤坏死因子Α 大鼠 

分 类 号：R285.5[医药卫生—中药学]