葡萄糖氯化钠钾注射液与甲硝唑注射液、替硝唑葡萄糖注射液配伍的稳定性  

Compatible stabilities of glucose and sodium chloride potassium chloride injection mixing with metronidazole and tinidazole for injection

作　　者：马爱玲[1] 陈晓辉[1] 魏京海[2] 毕开顺[1] 

机构地区：[1]沈阳药科大学药物分析教研室,110016 [2]首都医科大学附属北京儿童医院药剂科

出　　处：《中国实用医药》2008年第13期26-27,共2页China Practical Medicine

摘　　要：目的研究在室温下葡萄糖氯化钠钾注射液(简称GNK)分别与甲硝唑注射液、替硝唑葡萄糖注射液配伍后的稳定性。方法采用RP-HPLC法分别测定配伍后甲硝唑和替硝唑的含量变化,同时考察配伍溶液的外观、pH值和不溶性微粒的变化。结果在室温下配伍溶液8 h内均无气体或沉淀产生,pH值、不溶性微粒和含量均无明显变化。结论GNK与甲硝唑注射液、替硝唑葡萄糖注射液配伍后8 h稳定,在8 h内可安全应用于临床。Objective To observe the stabilities of glucose and sodium chloride potassium injection （GNK） mixing with metronidazole and tinidazole at 25℃. Methods RP-HPLC was applied to determine the content changing of metronidazole and tinidazole in different time. The pH, quantity of non-soluble particulate and appearance of mixtures were also observed. Results In room temperature the mixtures produced neither gas nor sediment. The pH,quantity of non-soluble particulate and content did not change within 8 hours. Conclusion The mixtures of GNK mixing with metronidazole and tinidazole were stable in 8 hours.

关 键 词：配伍稳定性 葡萄糖氯化钠钾注射液 甲硝唑 替硝唑 

分 类 号：R942[医药卫生—药剂学]