氟比洛芬对全身麻醉用药量影响的研究  

The effect of pre-operative flurbiprofen on anesthetics dosage during general anesthesia

作　　者：曾子代 张亚军[2] 刘春霞[2] Zeng zi dai, Zhang Yajun, Liu Chunxia, Che Hao, Zhou Liping（1.Anhua County of Hunan Province People＇s Hospital anesthesiologists, 413500 ;2.China-Japan Friendship Hospital, Beijing, 100029）

机构地区：[1]湖南省安化县人民医院麻醉科,413500 [2]卫生部中日友好医院,100029

出　　处：《中外健康文摘：医药月刊》2008年第3期34-35,共2页

摘　　要：目的探讨术前使用氟比洛芬对全身麻醉用药量的影响。方法75例接受同类手术的患者随机分成三组,每组25例。手术中静脉吸入复合维持麻醉。A组麻醉诱导前未使用氟比洛芬。B组麻醉诱导前静脉注射氟比洛芬1mg/kg。C组麻醉诱导前静脉注射氟比洛芬2mg/kg。手术中吸入笑气的浓度不变,根据血流动力学指标调节静脉麻醉药用量。记录手术时间、血流动力学指标、异丙酚与雷米芬太尼用量。结果三组患者的一般情况、手术时间相同。A组手术中异丙酚的用量为183.49±29.82mg,雷米芬太尼用量为563.45±9.61μg。B组手术中异丙酚的用量为171.18±34.82mg,雷米芬太尼的用量为496.44±69.07μg。C组异丙酚的用量为143.2±29.03mg,雷米芬太尼的用量为363.60±51.86μg。与A组相比,C组患者手术中异丙酚与雷米芬太尼用量减少（P〈0.05）。结论术前静脉注射氟比洛芬1mg/kg对手术中麻醉药用量影响不大。而静脉注射2mg/kg能明显减少手术中麻醉药用量。Objective：To investigate the effect of pre-operative flurbiprofen on anesthetics dosage during general anesthesia. Methods： Seventy-five patients were randomly allocated to 3 groups： Group A（n=25）： no pre-operative flurbiprofen. Group B （n=25） ： 1mg/kg flurbiprofen i. v. before anesthesia induction. Group C （n=25） ： 2mg/kg flurbiprofen i.v. before anesthesia induction. Anesthesia time, anesthestics usage and hemodynamic data were recorded. Results： No significant differences were found in the age, body mass index and surgery duration among the three groups. The mean dosage of propofol and remifentanyl in group A was 183. 49±29. 82mg and 563.45±9. 61μg respectively. The mean dosage of propofol and remifentanyl in group B was 171.18±34.82mg and 496.44±69.07μg respectively. The mean dosage of propofol and remifentanyl in group C was 143.2±29.03mg and 363. 60±51.86pg respectively. Compared with group A, propofol and remifentanyl dosage in group C was obviously reduced（P〈O. 05）. Conclusion： In our study, pre-operative flurbiprofen 1mg/kg dose not affect the anesthetic dosage, but pre-operative flurbiprofen 2mg/kg can reduce the anesthetics dosage.

关 键 词：氟比洛芬 全身麻醉 用药量 

分 类 号：R614.2[医药卫生—麻醉学;医药卫生—临床医学;医药卫生—外科学]