含席佛碱杯[4]芳烃衍生物的合成及其抗紫外抗氧化活性  

Synthesis and its anti-ultraviolet,anti-oxidation activity of calix[4]arene derivative containing Schiff-base fraction

作　　者：张晓梅[1] 蒋海英[1] 王少宝[1] 

机构地区：[1]安徽理工大学化学工程学院,安徽淮南232001

出　　处：《安徽大学学报（自然科学版）》2008年第2期70-73,共4页Journal of Anhui University(Natural Science Edition)

基　　金：安徽理工大学博士科研启动基金资助项目(DG541)

摘　　要：为研究抗紫外抗氧化性能为一体的功能有机物，设计合成含席佛碱片段的杯[4]芳烃衍生物4，用1HNMR、13CNMR、IR及MS（（Maldi—Tof））表征新化合物的结构．研究4在波长280—400nm范围内的紫外光谱，用DPPH·法测定4对自由基的清除率，结果表明，4在325nm处有明显的紫外吸收，有抗UVA活性；它对DPPH·的清除率达到34％，有一定的抗氧化活性．实验还发现，4的中间体5，11，17，23-四叔丁基-25，27-二羟基-26，28-二（酰肼基甲氧基）杯[4]芳烃3对自由基清除率很高，可达90％左右．For developing the functional organic compound with anti -ultraviolet and anti -oxidation activity simultaneously, calix [ 4 ] arene derivative containing Schiff - base fraction 4 was designed and synthesized. The structure of 4 was confirmed by 1HNMR, 13CNMR ,IR and MS（ Maldi -Tof）. Ultraviolet absorption spectrometry at range of 280 - 400 nm and the efficiency of radical scavenging of 4 were tested. The results showed that 4 demonstrated anti solar UVA activity due to its obvious ultraviolet absorption at 325nm and a certain anti - oxidation activity for the efficiency of radical scavenging of 34%. It＇s also found that compound 3, 4, 5, 11,17 - tert - butyl - 25,27 dihydroxyl - 26,28 di （ hydrazide group methoxyl） calix [4] arene, the intermediate of 4, was with high efficiency of radical scavenging about 90%.

关 键 词：杯[4]芳烃衍生物 席佛碱 抗紫外 抗氧化 

分 类 号：TQ242[化学工程—有机化工]