尿激酶对IgA肾病毛细血管密度的影响  

Effect of urokinase on capillary density in IgA nephropathy

作　　者：邱强[1] 孙雪峰[1] 陈香美[1] 洪权[1] 

机构地区：[1]中国人民解放军总医院全军肾脏病研究所暨肾病重点实验室,北京100853

出　　处：《军事医学科学院院刊》2008年第2期148-150,共3页Bulletin of the Academy of Military Medical Sciences

基　　金：国家自然科学基金面上项目(30470803);国家基础研究发展规划项目(2007CB507400)

摘　　要：目的:观察尿激酶治疗后IgA肾病毛细血管密度的变化。方法:观察不同病理程度下,IgA肾病毛细血管密度的变化,同时比较尿激酶治疗前后,10例重复肾活检IgA肾病患者的毛细血管密度变化。结果:①随着病变的加重,IgA肾病肾小球毛细血管袢密度、肾小管周围毛细血管密度均随之减小。②10例IgA肾病应用尿激酶治疗后,重复肾活检显示,治疗前后肾小球毛细血管袢密度(/肾小球)分别为:36.5±8.7和45.4±9.9,两者相比具有统计学差异(P<0.05),肾小管周围毛细血管密度(/肾小管)明显升高(治疗前0.9±0.2vs治疗后1.4±0.3,P<0.05)。结论:尿激酶治疗可能是通过增加肾小球和肾间质毛细血管的密度而延缓IgA肾病的进展。Objective： To analyze the effect of urokinase on the capillary density in IgA nephropathy. Methods： Capillary densities of IgA nephropathy of different pathologic degrees were observed. The capillary densities in repeated renal biopsies after urokinase treatment in 10 IgA nephropathy cases were compared with those before treatment. Results： With the aggravation of lesions, the glomerular and peritubular capillary densities in IgA nephropathy decreased. The glomerular and peritubular capillary densities were negatively correlated with the level of serum creatinine （ R^2 = 0. 6946 and R^2 = 0. 6271 , P 〈 0.001, respectively）. The results of repeated biopsies in 10 patients after urokinase treatment showed that glomerular capillary densities（36.5 ± 8.7 vs 45.4 ±9.9, P 〈 0.05） and tubulointerstitial capillary densities （ 0.9±0. 2 vs 1.4 ± 0. 3, P 〈 0.05 ） were significantly increased. Conclusion： Treatment with urokinase can increase the glomerular and tubulointerstitial capillary densities.

关 键 词：IGA肾病 毛细血管密度 尿激酶 尿纤溶酶原激活物 细胞外基质 

分 类 号：R692.3[医药卫生—泌尿科学]