静脉应用胺碘酮治疗老年人快速型心房纤颤临床观察  

Clinical observation on the amiodarone mainlining therapy for the AFS of the elderly

作　　者：戴萍[1] 范正宏[1] 

机构地区：[1]武汉市第一医院,湖北武汉430022

出　　处：《中国医院药学杂志》2008年第8期636-638,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：探讨静脉应用胺碘酮对老年人快速型心房纤颤的临床疗效及安全性。方法：对60例老年快速房颤患者治疗，胺碘酮150mg稀释于20mL生理盐水中，于10～15min内缓慢静脉注射，给药15～20min后无效者，可重复给药150mg，继之以0．5～1mg·min^-1速度持续静滴24h（24h总量〈1200mg）。观察房颤是否转复、心室率、血压及心电图QT间期变化。结果：房颤转复率75％（45／60）；心室率由治疗前（144±16．5）次／min减慢为（85．6±6．5）次／min，治疗前后心室率比较差异有显著性（P〈0．01）。治疗前后收缩压差异无显著性（P〉0．05）。治疗前后QT—c差异无统计学意义（P〉0．05）。结论：胺碘酮属Ⅲ类抗心律失常药物，主要电生理效应是延长各部心肌组织的动作电位及有效不应期，有利于消除折返激动，抑制心房及心肌传导纤维的快钠离子内流，减慢传导速度，减低窦房结自律性，静脉应用胺碘酮治疗老年人快速房颤疗效肯定，且用药安全。OBJECTIVE To study the clinical effect and safety of amiodarone therapy for AFS of the elderly. METHODS 60 cases were given with slow mainlining of amiodarone 150 mg diluted in 20 mL of normal saline solution for injection, 10-15 mL Min-1 ,the changes in recovery situation, ventricle rate, blood pressure and cardiogram in QT period were observed. RESULTS The recovery rate of AFS was 75%（45/60） while the ventricle rate decreased from 144±16.5 times·min^-1 to 85.6±6. 5 tims·min^-1. （P〉0. 01）. CONCLUSION In conclusion,the amiodarone mainlining therapy has positive curative effect for the AFS of the elderly.

关 键 词：胺碘酮 快速型心房纤颤 临床观察 

分 类 号：R972[医药卫生—药品]