血清甘胆酸筛查妊娠期肝内胆汁淤积症的优势探讨  

The Observation of Serum Cholyglycine Levels in Patients with Intrahepatic Cholestasis of Pregnancy

作　　者：余坷[1] 保勇[1] 贺晨[1] 

机构地区：[1]成都市第二人民医院核医学科,四川成都610017

出　　处：《标记免疫分析与临床》2008年第2期88-89,95,共3页Labeled Immunoassays and Clinical Medicine

摘　　要：为探讨空腹血清甘胆酸(CG)检测对于筛查妊娠期胆汁淤积症(ICP)患者的优势,本文对400名正常孕妇和87例胆淤症妊娠患者的空腹血清CG、总胆汁酸(TBA)、总胆红素(TBIL)及丙氨酸氨基转移酶(ALT)检测结果进行回顾性分析。结果显示,ICP组血清CG值非常显著高于正常组(P<0.001),其阳性率为100%,并早于TBA、TBIL和ALT,而后三者仅轻中度升高,阳性率分别为44.8%、11.5%和35.6%。因此,血清CG筛查为孕妇普查及时发现ICP的灵敏的经济的早期的血清学指标。To explore the clinical significance of empty abdominal serum Cholyglycine（CG） levels on the diagnosis of patient with Intrahepatic Cholestasis of Pregnancy（ICP）, the serum levels of CG, TBA, TBIL and ALT in 400 normal pregnant women and in 87 pregnant patients with ICP were analyzed retrospectively. The results showed that the serum CG levels of patients with ICP were significant higher than that of normal control （P〈0. 001）. The positive rate of serum CG was 100%. The serum levels of TBA, TBIL and ALT in patients with ICP were slightly higher than that of normal controls. The positive rates of TBA, TBIL and ALT were 36.5%, 12.2% and 35.6% respectively. The serum CG levels may be regarded as an economical and sensitive indicator in diagnosis of patients with ICP in the eaglier stage.

关 键 词：甘胆酸 灵敏度 妊娠期肝内胆汁淤积症 

分 类 号：R714.25[医药卫生—妇产科学]