纤维蛋白原水平与10年累积原发性高血压发病的关系  

Association Between Plasma Fibrinogen Concentration and Ten-year Accumulative Risk of Essential Hypertension

作　　者：成君[1] 赵冬[1] 王薇[1] 孙佳艺[1] 李岩[1] 秦兰萍[1] 吴兆苏[1] 

机构地区：[1]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病研究室,北京100029

出　　处：《中华高血压杂志》2008年第4期303-306,共4页Chinese Journal of Hypertension

基　　金：国家"八五"科技攻关课题(85-915-01-02);北京心血管病 高技术实验室资助项目(953850700)

摘　　要：背景研究表明,纤维蛋白原(FIB)水平不仅是心脑血管疾病发病的独立危险因素,而且与高血压的患病和发病有关。但在以往的研究中发现,FIB 与新发高血压之间的关系存在着性别差异,而在中国人群中,尚缺乏 FIB 与高血压发病之间关系的相关流行病学研究。目的探讨中国35～64岁人群血浆 FIB 水平与10年累积原发性高血压(EH)发病危险的关系。方法采用前瞻性队列研究的方法,对1992年在北京建立的一组35～64岁、无 EH 的队列人群共2115人的基线血浆 FIB 水平和10年累积 EH 发病的关系进行分析。结果 1)10年累积 EH发病率为34.8%,男性为39.3%,女性为31.5%,男女两性发病率的差异有非常显著意义(P<0.01);2)基线 FIB水平三分位与10年后血压水平分级的偏相关系数为0.096(P<0.01);3)随着基线 FIB 水平的升高,男性10年累积 EH 发病率从34.4%上升到43.1%,女性从28.7%上升到36.8%,差异均有统计学意义(P 均<0.05);4)与 FIB最低水平组相比,最高水平组10年累积高血压发病危险升高41%;男性发病危险升高44.7%,女性发病危险升高36.7%。结论随着血浆 FIB 水平的升高,EH 的发病风险增加;改善血液的高凝和高黏状态对心脑血管病的早期防治具有一定作用。Background Studies showed plasma fibrinogen （FIB） is not only the independent risk factor of cardiovascular disease but also associated with the prevalence and incidenc of hypertension. A gender difference was shown in the association of FIB with hypertensionj while no epidemiological study has been reported in Chinese population. Objective To explore the association between plasma FIB concentration and ten-year accumulative risk of hypertension. Methods A prospective study of relationship between blood pressure and other traditional risk factors were carried out in a cohort of Chinese population of 2115 people aged 35-64 years old in 1992 and 2002. The association of plasma FIB concentration with ten-year accumulative risk of hypertension was analyzed. Results The ten-year accumulative incidence rate of hypertension was 34.8% , and incidence in males （ 39. 3 % ） was significantly higher than that in females （31.5 % ） （P〈0.01 ）. Partial correlation coefficient of baseline FIB tertiles with ten-year blood pressure levels was 0. 096 （ P〈0. 01 ）. Ten-year accumulative incidence rate of hypertension was increased with the elevated baseline FIB tertiles in both males and females （P〈0.05）. Multivariable OR （95% CI） of accumulative incident hypertension in the highest FIB tertile was 1. 410 （ 1. 124 to 1. 769） compared with the lowest tertile. Conclusion The risk of incident hypertension increases with elevated plasma FIB concentration. Treatment tar;teting; blood hyoercoagulation for orevention of cardiovascular diseases is warranted.

关 键 词：原发性高血压 纤维蛋白原 发病危险 

分 类 号：R544.1[医药卫生—心血管疾病]