血库型白细胞过滤器在临床输血中的应用观察  

Application of blood bank type white blood cell filter in the clinical blood transfusion

作　　者：黄丽雅[1] 孙爱农 

机构地区：[1]中山市人民医院输血科,广东中山528400 [2]中山市红十字中心血站,广东中山528403

出　　处：《国际医药卫生导报》2008年第8期72-76,共5页International Medicine and Health Guidance News

摘　　要：目的观察国产血库型白细胞过滤器在临床输血中的应用效果。方法取保存期在6～10d的红细胞悬液进行白细胞过滤，检测过滤前后红细胞、白细胞计数，观察白细胞过滤和未过滤各300例患者中的非溶血性发热性输血反应（FNHTR）发生情况。结果红细胞悬液经过滤后，残余白细胞平均为4．2×10^6／L，白细胞清除率平均为99．95％，过滤前后白细胞含量有显著性差异（t=15．41，P〈0．01），红细胞回收率平均为92．71％;红细胞悬液未过滤时临床发生FNHTR8．67％（26／300），白细胞过滤后，FNHTR降至0．67％（2／300）；滤前及滤后1～6天内，红细胞悬液的上清游离血红蛋白和红细胞LDH差异无显著性变化。结论国产一次性白细胞过滤器可有效预防FNHTR的发生。Objective To observe the effect of the white blood cell filter made by China in clinical blood trasfusion. Methods Red blood cell suspensions of storaged 6-10days are carry on filter the white blood cells, examining the number of white and red blood cells in filter circa, Observe the white blood cells filters and dids not filter 300 for each the febrile nonhemolytic transfusion reaction（FNHTR） within sufferer occurrence circumstance. Result The red blood cell suspensions after the filtration, remaining white blood cell average for 4.2×10^6/L, white blood cell percentage clearance average 99.95%, around filtration white blood cell content extremely remarkable difference （t=15. 41, P〈0.01）, red blood cell recovery rate average 92.71%;when red blood cell suspensions no filter clinical has ENHTR 8. 67%（26/300）,after the white blood cell filtration, FNHTR falls to 0.67%（2/300）, Front filters and filters in the latter 1-6 day, the red blood cell suspensions on clear dissociation hemoglobin and the red blood cell LDH difference non-significance change. Conclusion The domestically produced disposable white blood cell filter may prevent FNHTR effectively the occurrence.

关 键 词：白细胞 过滤器 红细胞悬液 输血反应 

分 类 号：R4[医药卫生—临床医学]