SBA-15固载脯氨酸催化剂的制备及其在不对称Mannich反应中的应用  

Immobilization of L-Proline on SBA-15 and Its Application in Asymmetric Mannich Reaction

作　　者：孙彩霞[1] 李海岗[1] 吴海虹[1] 刘月明[1] 吴鹏[1] 

机构地区：[1]华东师范大学化学系上海市绿色化学与化工过程绿色化重点实验室,上海200062

出　　处：《催化学报》2008年第4期351-355,共5页

基　　金：国家自然科学基金(20602012;20533010);上海市科委项目(07QA14017;06SR07101);上海市重点学科建设项目(B409)

摘　　要：以4-羟基-L-脯氨酸为原料合成了脯氨酸衍生物,并将其固载于介孔SBA-15分子筛上制备了Pro/SBA-15催化剂.用X射线衍射、N2吸附-脱附、扫描电镜和红外光谱等手段对Pro/SBA-15催化剂进行了表征,并考察了催化剂在不对称Mannich反应中的催化性能.结果表明,固载脯氨酸不影响SBA-15的有序介孔结构,只是其孔径、孔体积和BET比表面积有所减小,在不对称Mannich反应中具有较高的催化活性和对映选择性.与均相催化相比,以对硝基苯甲醛为反应物时可得到较高的分离收率(80%)和中等的对映选择性(ee=60%).催化剂通过简单分离后可重复使用4次以上,其催化性能基本保持不变.The novel Pro/SBA-15 catalyst was prepared using SBA-15 zeolite as the support to immobilize L-proline （Pro） derivatives, which was synthesized from 4-hydroxy-L-proline. The Pro/SBA-15 catalyst was characterized by X-ray diffraction, N2 adsorption-desorption, scanning electron microscopy, and infrared spectroscopy. The catalytic performance of the catalyst was measured for asymmetric Mannich reaction. The results indicated that the mesoporous structure of SBA-15 was not affected by immobilization, however, the pore diameter, pore volume, and BET surface area were decreased. The Pro/SBA-15 catalyst had higher catalytic activity and enantioselectivity. Using 4-nitrobenzaldehyde as the reactant, the Mannich reaction product was obtained with high yield （80 % ） and moderate enantioselectivity （ee = 60 % ）. The supported catalyst could be easily separated from the reaction system and reused at least four times without loss of activity and enantioselectivity.

关 键 词：4-羟基-L-脯氨酸 SBA-15分子筛 负载型催化剂 不对称Mannich反应 对硝基苯甲醛 

分 类 号：O643.36[理学—物理化学]