Ang(1-7)和依那普利拉对大鼠严重烧伤早期心脏保护作用的研究  

Protective effects of Ang(1-7) and Enalaprilat to heart at early stage following severe bums in rats

作　　者：雷泽源[1] 黄跃生[1] 肖蓉[1] 张兵钱[1] 朱成玲[2] 

机构地区：[1]第三军医大学西南医院全军烧伤研究所,创伤,烧伤与复合伤国家重点实验室,重庆400038 [2]第三军医大学西南医院中心实验室,重庆400038

出　　处：《现代生物医学进展》2008年第7期1242-1244,共3页Progress in Modern Biomedicine

基　　金：国家重点基础研究发展规划项目("973"项目;2005CB522601);军队"十一五"专项课题(06Z033)

摘　　要：目的:观察Ang(1-7)和依那普利拉对烧伤早期心功能及心肌损伤的保护作用。方法:健康雄性Wistar大鼠24只,随机分为正常组、烧伤组、Ang(1-7)组和依那普利拉组。于烧伤后6H检测血流动力和心肌力学指标(SBP,DBP,LVSP,LVEDP,+LVdp/dt-_(max),-LVdp/dt_(max)),血清cTnI,及血清和心肌组织中AngⅡ含量变化。结果:ACEi组和Ang(1-7)组SBP,DBP,LVSP,+LVdp/dt-_(max),-LVdp/dt_(max)较烧伤组均明显增高(P<0.01),LVEDP和血清cTnI明显降低(P<0.01),ACEi组血清和心肌中AngⅡ较烧伤组明显降低(P<0.01)。结论:Ang(1-7)和ACEi均能有效的改善大鼠烧伤早期心功能,减轻心肌损伤。Objective： To investigate Protective effects of Ang （ 1-7 ） and Enalaprilat to rat heart function and myocardial damage following severe burns in rats. Methods： 24 male Wistar rats were inflicted with 30% TBSA of full-thickness burns. The rats were grouped as control group （normal group ）, scald group, Ang（ 1-7 ）group and Enalaprilat group （ACEi group ）. Hemodynamics and myocardial mechanics index （ SBP, DBP, LVSP, LVEDP, ＋LVdp/dtmax, -LVdp/dtmax）, level of serum cTnⅠ, AngⅡ and myocardial AngⅡ was determined after 6h postburn. Results： SBP, DBP, LVSP, ＋LVdp/dtmax, -LVdp/dtmax of Ang（ 1-7 ）group and Enalaprilat group increased obviously after 6h postburn （P〈0.01 ）, -LVdp/dtmax and serum cTnⅠ obviously decreased （P〈0.01 ）. Level of serum and myocardial AngⅡ decreased obviously in Enalaprilat group （P〈0.01 ）. Conclusion： Ang （ 1-7 ） and enalaprilat may improve left ventricle function and mitigate myocardial injury.

关 键 词：Ang(1-7) 依那普利拉 血流动力学 心肌力学 心肌钙蛋白Ⅰ 

分 类 号：R644[医药卫生—外科学]