乙型肝炎病毒宫内感染危险因素的病例对照研究  

Case-control study on the risk factors for hepatitis B virus intrauterine infection

作　　者：于鸿志[1] 徐德忠[1] 承海[1] 闫永平[1] 曹引丽 徐剑秋 张志国 王琰[1] 

机构地区：[1]第四军医大学流行病教研室,陕西西安710032 [2]陕西省妇幼保健医院产科,陕西西安710032

出　　处：《现代生物医学进展》2008年第7期1289-1291,1301,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金(30230320)

摘　　要：目的:探讨与乙型肝炎病毒宫内感染相关的产妇孕期危险因素。方法:采用病例对照的研究方法,选择连续收集的2005年10月至2006年10月在陕西省妇幼保健院产科行孕期检查并分娩的113例乙型肝炎病毒表面抗原(HBsAg)阳性产妇及其所产新生儿为研究对象,以出生时血清HBsAg阳性的新生儿为病例组,其余均为对照组,收集产妇孕期及产时的相关资料,采用单因素分析、对数线性模型等方法分析与宫内感染相关的因素。结果:113例新生儿有3例发生宫内感染。病例组产妇孕中期有性行为、HBV DNA阳性与对照组之间存在统计学差异(P<0.05),且交互作用分析显示二者之间符合相乘模型,OR值及95%CI为127.00(4.73-340.51),有协同作用。其他因素与HBV宫内感染无统计学关联。结论:孕中期性行为及产妇HBVDNA阳性可能增加新生儿HBV宫内感染的危险性。Objective： To explore the risk factors of hepatitis B virus intrauterine infection. Methods： Case-control study was employed, and 113 hepatitis B surface antigen （HBsAg） positive pregnant women and their newborns were collected and examined by ELISA test. HBsAg positive newborns were selected as cases, others as controls. The information during pregnancy and delivery was collected and analyzed with univariate analysis, and log-linear model to determine the correlation between these factors and intrauterine infection. Results： 3 of 113 newborns were identified as HBsAg positive due to intrauterine infection. The difference of sexual behavior during pregnancy and HBV DNA positive between the cases and the controls was significant （P〈0.05）, and the interaction accorded to multiplicative relative risk model, with OR 127.00 （95% CI： 4.73-340.51 ）. Other factors were not significantly different between two groups. Conclusions： Sexual behavior during pregnancy and HBV DNA positive of pregnant women may contribute to HBV intrauterine infection.

关 键 词：乙型肝炎病毒 宫内感染 危险因素 

分 类 号：R512.62[医药卫生—内科学]