甲真菌病患者外周血淋-巴细胞免疫表型的分析  

Analysis of lymphocyte immunophentypes in peripheral blood of onychomycosis patients with flow cytometry

作　　者：盛宇[1] 石峰[2] 刘俊才 李鹤玉[1] 

机构地区：[1]哈尔滨医科大学附属第一临床医学院皮肤科,150001 [2]黑龙江省医院 [3]黑河市第一人民医院

出　　处：《国际免疫学杂志》2008年第1期8-9,共2页International Journal of Immunology

摘　　要：目的探讨甲真菌病患者外周血淋巴细胞免疫表型的情况。方法应用流式细胞仪对24例甲真菌病患者及20例健康人的外周血淋巴细胞亚群和自然杀伤细胞进行测定与分析。结果甲真菌患者外周血CD8^＋淋巴细胞明显高于健康对照组（P〈0．05），而CD3^＋细胞，CD4^＋细胞，CD4^＋／CD8^＋、CD19^＋细胞、CD16^＋CD56^＋细胞与对照组变化不明显。结论甲真菌患者存在着一定程度的细胞免疫异常，以CD8^＋细胞介导的免疫反应占主要地位。Objective To evaluate the immunological competence in peripheral blood of the patients with onychomycosis. Methods The lymphocyte subpopulations and natural killer cells in the peripheral blood of 24 patients and a control group of 20 individuals were analysed by flow cytometry. Results The percentage of suppressor CD8 ^＋ lymphocytes in the patients were significantly higher than that in the normal controls （P 〈0.05 ）. No statistically significant difference was obtained in the percentages of CD3 ^＋ lymphocytes, CD4^＋ lymphocytes, CD19^＋ lymphocytes, CD16^＋, CD56^＋ lymphocytes. Conclusion CD8 ^＋ lymphocytes plays an importand role in mediating the cell mediated immunity in onyehomyeosis.

关 键 词：甲真菌病 淋巴细胞亚群 流式细胞仪 

分 类 号：R756[医药卫生—皮肤病学与性病学]