实时谐波超声造影技术定量评价正常人肾脏皮质灌注  

Quantitative Evaluation of Real Time Contrast-enhanced Ultrasonography in Normal Renal Cortex Perfusion

作　　者：董怡[1,2] 王文平[2] 丁红[2] 范培丽[2] 曹佳颖[2] 林希元[2] 

机构地区：[1]复旦大学附属华山医院超声医学科,上海市200040 [2]复旦大学附属中山医院超声科

出　　处：《中国医学计算机成像杂志》2008年第2期160-164,共5页Chinese Computed Medical Imaging

基　　金：上海市重点学科建设项目资助,编号:B112~~

摘　　要：目的:评价实时谐波超声造影技术定量分析正常人肾脏灌注的可行性。材料和方法:采用PHILIPS I-U-22超声仪器对45例正常人进行双肾实时超声造影,超声对比剂为SonoVue,每侧肾脏使用剂量为1ml。每次原始数据经过Qlab灌注定量分析软件处理。比较双肾皮质超声灌注的差异,并用TIC曲线对肾脏皮质设置不同感兴趣区域(region of interest,ROI)进行定量灌注参数对比分析。结果:实时超声造影能清晰显示肾脏皮质灌注的过程。左肾与右肾皮质同一灌注参数无显著性差异,不同ROI测得的达峰时间、曲线下降支斜率之间无显著性差异,而曲线下面积、达峰强度绝对值、曲线上升支斜率之间有显著性差异。结论:实时谐波超声造影技术能定量分析肾脏皮质血流灌注的特点,不同的ROI在同一灌注参数的测量上具有一致性。Purpose： To evaluate the feasibility of real time contrast - enhanced ultrasonography （CEUS） in quantitative analysis of normal renal cortex perfnsion.Materials and Methods： Forty- five healthy volunteers were included in our research, real time contrast - enhanced harmonic imaging of renal blood perfnsion were collected successively, and a time - intensity curve （TIC） was created with system＇ s Qlab software, SonoVue was used in CEUS, 1 ml for each kidney. All quantitative data were compared between two kidneys and different regions of interest（ROIs） , Results： CEUS enjoyed clear imaging of kidney cortex perfnsion. Compared between two kidneys, there was no statistical difference between quantitative data, Differences in area under curve （AUC） , derived peak intensity（DPI） and slope rate of ascending curve（A）between different ROIs were statistically significant （P 〈 0.005）. How- ever the slope rate of descending curve（a）, time to peak（TTP） have no statistical difference. Conclusion： CEUS can precisely display the quantitative perfnsion of renal cortex. Perfnsion data of different ROI setting have concordance to some extent.

关 键 词：肾脏皮质 实时超声造影 定量分析 

分 类 号：R445.1[医药卫生—影像医学与核医学]