胰岛素、干细胞因子和Cajal间质细胞在糖尿病胃轻瘫中的作用  

Roles of Insulin, Stem Cell Factor and Interstitial Cells of Cajal in Diabetic Gastroparesis

作　　者：吴高珏[1] 林琳[1] 

机构地区：[1]南京医科大学第一附属医院消化科,210029

出　　处：《胃肠病学》2008年第4期249-251,共3页Chinese Journal of Gastroenterology

基　　金：江苏省自然科学基金项目(No.BK2004158);国家重点基础研究发展计划(2006CB503900)资助

摘　　要：糖尿病胃轻瘫是糖尿病的常见并发症,严重影响患者的生活质量和血糖控制。胃肠道Cajal间质细胞在维持胃肠功能中发挥重要作用,糖尿病胃组织中存在Cajal间质细胞数量和结构的异常改变,从而影响胃动力。胰岛素、干细胞因子对糖尿病胃肠道Cajal间质细胞的病变具有重要调控作用。本文就胰岛素、干细胞因子和Cajal间质细胞在糖尿病胃轻瘫中的作用作一综述。Diabetic gastroparesis is one of the common complications of diabetes mellitus, which affects seriously the patients＇ quality of life and the control of their blood glucose. Interstitial cells of Cajal （ICC） plays an important role in maintaining functions of gastrointestinal tract. It has been shown that ICC changes abnormally in gastric tissues of patients with diabetes mellitus, which contributes to the diabetic gastroparesis. It is reported that insulin and stem cell factor （SCF） play key roles in the control of the abnormalities of ICC in gastrointestinal tract of patients with diabetes mellitus. This article reviewed the role of insulin, SCF and ICC in the pathogenesis of diabetic gastroparesis.

关 键 词：糖尿病胃轻瘫 CAJAL间质细胞 胰岛素 干细胞因子 

分 类 号：R587.2[医药卫生—内分泌]