钙离子信号对胰岛素分泌的调控  

The Mechanism of Calcium Signaling Regulating Insulin Secretion

作　　者：董永明[1] 张铭[1] 林显光[1] 周围[1] 谢丽[1] 

机构地区：[1]华中科技大学生命科学与技术学院,湖北武汉430074

出　　处：《现代生物医学进展》2008年第5期937-939,共3页Progress in Modern Biomedicine

基　　金：国家973基金项目资助(2004CB720000)

摘　　要：胰岛素的分泌及其分泌的调控是维持机体内葡萄糖平衡的重要机制,胰岛素分泌量的不足会导致非胰岛素依赖的糖尿病的发生。胰岛素包裹在致密核心大囊泡中,胰腺β细胞通过调控致密核心大囊泡的胞吐过程来调节胰岛素的分泌。胞内Ca^(2+)浓度是影响胰岛素分泌的重要因素。胰腺β细胞主要通过质膜上的ATP敏感的钾通道、钙通道和胞内钙库的活动改变胞内Ca^(2+)浓度,从而调控β细胞胰岛素的分泌活动。The mechanism of insulin secretion is important in glucose metabolism. The deficiency of insulin secretion from pancreatic βcells will result in non-insulin dependent diabetes mellitus. In the pancreatic βcells, the insulin secretion is regulated by calcium-dependent regulative exocytosis of large dense-cored vesicles. Intracellular Ca^2＋ plays an important role in regulating insulin-containing granules.The pancreatic βcells could change concentration of intracellular Ca^2＋ by membrane KATP channels, Ca^2＋ channels and intracellular Ca^2＋ pools, which regulates insulin secretion in pancreatic βcells.

关 键 词：胞内钙离子 胰岛素 分泌囊泡 钙库 

分 类 号：Q455[生物学—生理学] Q578