腺相关病毒载体介导的基因打靶技术的研究进展  

Research Development on Adeno-Associated Virus-Mediated Gene Targeting

作　　者：刘杰[1] 房春红[1] 

机构地区：[1]西北农林科技大学生命科学学院,陕西杨凌712100

出　　处：《现代生物医学进展》2008年第5期982-985,共4页Progress in Modern Biomedicine

摘　　要：基因打靶技术在基因治疗和基因功能研究方面都有重要作用,而基因导入系统的有效性是影响中靶效率的重要因素。AAV (腺相关病毒)载体介导的基因打靶在保证有效转移DNA的同时,还具有非致病性、宿主范围广、高中靶效率和高保真性等诸多优点,使AAV成为目前人类基因治疗研究中最理想的病毒载体之一。本文就近几年AAV介导基因打靶的研究进展作一综述。Gene targeting plays an important role in the study ofgene therapy and genetic function. Potent gene-delivery system has an important influence on gene-targeting frequency. AAV （Adeno-Associated Virus ）-mediated gene targeting not only makes sure of potent DNA delivery, but also has many other virtues, including non-mutagen, wide host range, high gene-targeting frequency and high fidelity.AAV is one of the most idealistic viral vectors in human gene therapy at present. This review describes the research development of AAV-mediated gene targeting in recent years.

关 键 词：腺相关病毒 基因打靶 优点 分子机理 应用 

分 类 号：Q78[生物学—分子生物学] Q813