CCR5基因多态性与尖锐湿疣的关系  

Relationship between CCR5 Gene Polymorphism and Condyloma Acuminata

作　　者：左亚刚[1] 王宝玺[1] 刘秀荣[1] 赵芃[1] 阎倩姝[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730

出　　处：《中国医学科学院学报》2008年第1期95-97,共3页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(30740025);教育部高等学校博士点基金(20070023066)~~

摘　　要：目的探讨CCR5△32基因多态性与尖锐湿疣的关系。方法收集60例尖锐湿疣患者和50例健康对照者的DNA标本,采用PCR方法扩增CCR5基因片段,比较两组的基因型差别。结果60例尖锐湿疣和50例健康对照者中均未发现突变型CCR5△32基因型。结论CCR5△32基因多态性与尖锐湿疣无相关性。Objective To investigate the relationship between CCR5 Δ32 gene polymorphism and condyloma acuminata. Methods We used polymerase chain reaction to amplify the CCR5 gene fragments in 60 patients with condyloma acuminata and 50 age- and sampling date-matched controls, and compared the difference of genotypes between these two groups. Results No genotype difference was found between these two groups. Conclusion Condyloma acuminata are not associated with genetic polymorphism of CCR5 Δ32 gene.

关 键 词：CCR5Δ32基因多态性 尖锐湿疣 人乳头瘤病毒 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]