H_2O-PEG体系中Pd(OAc)_2催化合成查耳酮的研究  

Syntheses of chalcones in the aqueous medium of H_2O-PEG

作　　者：辛炳炜[1] 

机构地区：[1]德州学院化学系,山东德州253023

出　　处：《化学试剂》2008年第5期362-364,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(20571063)

摘　　要：发展了一种查耳酮的绿色合成体系。以Pd(OAc)2为催化剂,在H2O-PEG 2000体系中通过苯甲酰氯和苯乙烯基硼酸的偶联反应,高产率地合成了3种查耳酮。使用H2O-PEG 2000最突出的特点是催化效率高,Pd(OAc)2用量仅为0·2mol%。该水相体系不需要膦配体,反应条件温和、反应时间短并且产率高,是制备查耳酮的理想绿色体系。The palladium acetate-catalyzed synthesis of chalcone in water in the presence of polyethylene glycol（ PEG 2000） was described. The catalytic efficiency in Pd（OAc）2-PEG system was higher than that in organic systems,with the Pd（OAc）2 consumption equating to merely 0.2 mol%. Compared with the previous methods in organic systems, the aqueous medium was active, air stable, recyclable, which could avoid the use of expensive and environmentally unfavorable phosphine ligand. It was proved to be a desire green system.

关 键 词：查耳酮 苯乙烯基硼酸 水 聚乙二醇(PEG) 偶联反应 

分 类 号：O625.4[理学—有机化学]