2-氨基噻唑-5-甲酸甲酯和2-溴噻唑-5-甲酸甲酯的简便合成  

A simple synthesis of methyl 2-aminothiazole-5-carboxylate and methyl 2-bromothiazole-5-carboxylate

作　　者：王莹[1] 匡永清[1] 罗成礼[1] 孟丽丽[1] 

机构地区：[1]湖南大学化学化工学院,湖南长沙410082

出　　处：《化学试剂》2008年第5期385-386,共2页Chemical Reagents

基　　金：淮安市科技发展计划项目(HAG03040)资助

摘　　要：以β-甲氧基丙烯酸甲酯、N-溴代丁二酰亚胺、水和硫脲为原料,采用一锅法制得2-氨基噻唑-5-甲酸甲酯,产率71%;再通过重氮化-溴化反应合成2-溴噻唑-5-甲酸甲酯,产率68%。The one-pot reaction of methyl β-methoxyacrylate, N- bromosuccinimide,H2O and thiourea afforded methyl 2-aminothiazole-5-carboxylate in 71% yield, which was transformed into methyl 2-bromothiazole-5-carboxylate in 68% yield via diazotization and bromination with the NaNO2-NaBr-CuSO4 system.

关 键 词：β-甲氧基丙烯酸甲酯 2-氨基噻唑-5-甲酸甲酯 2-溴噻唑-5-甲酸甲酯 一锅法 合成 

分 类 号：O626[理学—有机化学]