延胡索总生物碱对小鼠抗应激能力的研究  

An Experimental Study on the Anti-stress Effects of Alkaloids in Rhizoma Corydalis to Mice

作　　者：白雪[1] 肖海涛[1] 杨杰[1] 朱洁[1] 郝小燕[1] 

机构地区：[1]贵阳医学院药学院

出　　处：《贵阳医学院学报》2008年第2期139-140,147,共3页Journal of Guiyang Medical College

基　　金：贵州省科技厅基金资助项目[黔科合J字(2005)2068号]

摘　　要：目的:观察延胡索总生物碱(Alkaloids of rhizoma corydalis,ARC)对小鼠抗应激能力的影响。方法:60只小鼠随机分为5组:正常对照组,ARC低剂量组、ARC中剂量组、ARC高剂量组,阳性药对照组;灌胃给药后,检测小鼠自主活动次数、杆停留时间、常压耐缺氧能力。结果:与正常对照组相比,ARC各组小鼠自主活动次数减少,杆停留时间延长,常压耐缺氧能力提高。结论:ARC能增强小鼠抗疲劳能力和耐缺氧能力,提高小鼠的抗应激能力。Objective： To observe the effects of alkaloids in rhizoma corydalis （ARC） on anti-stress abihty of mice. Methods： Sixty mice were randomly divided into five groups： normal control group, low ARC dosage group, middle ARC dosage group, high ARC dosage group and positive control group （treated with Brain-healthy capsules）. After oral administration, autonomic activities, creeping-sustained time, and hypoxia tolerance ability under normal pressure of mice were observed. Results： Mice in ARC groups showed less autonomic activities, longer creeping-sustained time＇, and stronger ability of anti-fatigue and anti-hypoxia compared with mice in normal control group. Conclusion： ARC can improve anti-fatigue and anti-hypoxia ability and enhance the ability of stress response in mice.

关 键 词：延胡索 生物碱 应激 缺氧 疲劳 小鼠 

分 类 号：Q949.748[生物学—植物学] Q046.88